Evaluating the Impact of Eosinophil Count on the Long-term Clinical Outcomes of Patients With an Acute ST-segment Elevation Myocardial Infarction Who Require Emergency Percutaneous Coronary Intervention:Results of a Multicenter Cohort Study  

作　　者：Lei Guo Hao Liu Zhichao Dong Xuchen Zhou Hao Zhu Xia Gu Bo Zhang 

机构地区：[1]Department of Cardiology,the First Affiliated Hospital of Dalian Medical University,Dalian,Liaoning 116011,China [2]Department of Cardiology,the Second Affiliated Hospital of Harbin Medical University,Harbin,Heilongjiang 150086,China

出　　处：《Cardiology Discovery》2024年第4期274-279,共6页心血管病探索(英文)

基　　金：supported by the National Natural Science Foundation of China(82100529);the Medical,Dalian Medical Science Research Program Project(Peak Climbing Program)(2023DF033);Clinical Youth Scientific Research Project of Harbin Medical University(2020-KYYWF-1459).

摘　　要：Objective:Eosinophils(EOS)are inflammatory innate immune cells that play an important role in arterial thrombogenesis.There is a paucity of data on whether EOS levels have an impact on long-term outcomes following ST-segment elevation myocardial infarction(STEMI).This study aimed to investigate the impact of EOS count on the clinical outcomes of STEMI patients who underwent emergency percutaneous coronary intervention(PCI).Methods:This is a retrospective multicenter cohort study.A total of 754 patients with STEMI who required emergency PCI at 5 centers were screened between October 2015 and November 2016.Patients were divided into 2 groups based on EOS count:EOS count<0.02×10^(9)/L group(n=264)and EOS count≥0.02×10^(9)/L group(n=490).Baseline demographic characteristics,clinical information,and medical test data were collected at study entry.The primary endpoint was all-cause death.The secondary endpoint was a major adverse cardiac event.Multivariablete Cox regression analysis was performed to identify the independent predictors of all-cause death,with a follow-up period of 5 years.Results:The incidence of all-cause death(14.8%vs.7.6%,P=0.002)and major adverse cardiac event(20.1%vs.13.1%,P=0.011)were significantly higher in EOS count<0.02×10^(9)/L group compared with≥0.02×10^(9)/L group.Multivariablete Cox regression analysis showed that an EOS count<0.02×10^(9)/L,age≥65 years,previous heart failure,previous stroke,and left ventricular ejection fraction≤40%were independent predictors of all-cause death in patients with STEMI who underwent an emergency PCI.Conclusions:Low EOS counts were associated with all-cause mortality in STEMI patients who underwent emergency PCI.

关 键 词：EOSINOPHILS ST-segment elevation myocardial infarction Percutaneous coronary intervention OUTCOMES Coronary artery disease 

分 类 号：R54[医药卫生—心血管疾病]