PCT、WBC联合CRP在ICU呼吸感染中的表达、诊断价值及与CPIS评分的相关性分析  

Expression,Diagnostic Value,and Correlation Analysis of PCT,WBC,and CRP with CPIS Score in ICU Respiratory Infections

作　　者：遆露莹 杨红玉 李丽[2] 王冬梅 袁亚松 张博 TI Luying;YANG Hongyu;LI Li;WANG Dongmei;YUAN Yasong;ZHANG Bo(Department of Critical Care Medicine,Zhuozhou Hospital,Zhuozhou Hebei 072750,China;Department of Laboratory,Zhuozhou Hospital,Zhuozhou Hebei 072750,China)

机构地区：[1]涿州市医院重症医学科,河北涿州072750 [2]涿州市医院检验科,河北涿州072750

出　　处：《昆明医科大学学报》2025年第1期136-141,共6页Journal of Kunming Medical University

基　　金：保定市科技计划项目(2441ZF165)。

摘　　要：目的分析降钙素原(PCT)、白细胞计数(WBC)联合C反应蛋白(CRP)在重症监护室(ICU)呼吸感染中的表达、诊断价值及与临床肺部感染评分(CPIS)的相关性。方法选取2019年3月至2024年6月涿州市医院ICU呼吸感染患者105例为观察组,另外选取于ICU未发生呼吸感染117例患者为对照组。通过Zybio-Q7型免疫定量分析仪对两组PCT水平进行检测,通过XT-4000i型白细胞分析仪对两组WBC水平进行检测,通过免疫比浊法对两组CRP水平进行检测。分析PCT、WBC、CRP的表达变化与ICU呼吸感染临床特征、CPIS评分的关系及对ICU呼吸感染的诊断价值。结果观察组入住ICU时间(>15 d)和机械通气时间(>7 d)的占比显著高于对照组(P<0.05)。与对照组比较,观察组PCT、WBC、CRP水平和CPIS评分升高,差异具有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,入住ICU时间>15 d(OR=4.087)、PCT(OR=6.543)、WBC(OR=2.652)和CRP(OR=8.964)为影响ICU呼吸感染发生的危险因素。PCT、WBC、CRP与CPIS评分之间Pearson相关性分析显示,PCT、CPIS评分之间正相关(r=0.925,P=0.001);WBC、CPIS评分之间正相关(r=0.739,P=0.001);CRP、CPIS评分之间正相关(r=0.948,P=0.001)。ROC曲线显示,三项联合对ICU呼吸感染的诊断价值高于PCT、WBC、CRP单项诊断(P=0.002)。结论PCT、WBC联合CRP对ICU呼吸感染的诊断价值较高,且与CPIS评分呈正相关,因此上述指标可为ICU呼吸感染的早期诊断提供可靠依据。Objective To analyze the expression and diagnostic value of procalcitonin(PCT),white blood cell count(WBC),and C-reactive protein(CRP)in respiratory infections in the intensive care unit(ICU),and their correlation with the clinical pulmonary infection score(CPIS).Methods A total of 105 patients with respiratory infections admitted to the ICU from March 2019 to June 2024 were selected as the observation group,while 117 patients with no respiratory infection in the ICU were selected as the control group.PCT levels in both groups were measured using the Zybio-Q7 immunoquantitative analyzer,WBC levels were measured using XT-4000i white blood cell analyzer,and CRP levels were measured using the immunoturbidimetric method.The relationship between the expression of PCT,WBC and CRP and the clinical characteristics and CPIs score of respiratory infection in ICU were analyzed.Results The proportion of patients in the observation group with ICU stay>15 days and mechanical ventilation>7 days was significantly higher than that in the control group(P<0.05).Compared to the control group,the levels of PCT,WBC,CRP and CPIS score in the observation group were elevated,with statistically significant differences(P<0.05).Multivariate logistic regression analysis showed that ICU stay>15 days(OR=4.087),PCT(OR=6.543),WBC(OR=2.652),and CRP(OR=8.964)were risk factors for the occurrence of respiratory infections in the ICU.Pearson correlation analysis indicated a positive correlation between PCT and CPIS scores(r=0.925,P=0.001),a positive correlation between WBC and CPIS scores(r=0.739,P=0.001);and a positive correlation between CRP and CPIS scores(r=0.948,P=0.001).The ROC curve demonstrated that the combined diagnostic value of the three markers for ICU respiratory infections was higher than that of PCT,WBC,or CRP alone(P=0.002).Conclusion The combination of PCT,WBC,and CRP has high diagnostic value for ICU respiratory infections and is positively correlated with CPIs scores.Therefore,the above indicators can provide a reliable basis for

关 键 词：重症监护室呼吸感染 降钙素原 白细胞计数 C反应蛋白 临床肺部感染评分 

分 类 号：R563.1[医药卫生—呼吸系统]