柴胡疏肝汤对痰气郁结型癫痫患儿脑电波、炎症因子及认知功能改善作用的研究  

Effects of Chaihu Shugan Decoction on Brain Waves,Inflammatory Factors,and Cognitive Function in Children with Epilepsy of Phlegm-Qi Stagnation Type

作　　者：李怡静 石宏 庞素玲 孙萌萌 李依婷 娄永亮 王松江 LI Yijing;SHI Hong;PANG Suling;SUN Mengmeng;LI Yiting;LOU Yongliang;WANG Songjiang(Kaifeng Central Hospital,Kaifeng 475000,China)

机构地区：[1]开封市中心医院,河南开封475000

出　　处：《中医药信息》2025年第1期62-66,共5页Information on Traditional Chinese Medicine

基　　金：河南省医学科技攻关计划项目(LHGJ20220157)。

摘　　要：目的:探讨柴胡疏肝汤对痰气郁结型癫痫患儿脑电波、炎症因子及认知功能的改善作用。方法:选取符合纳入标准的206例痰气郁结型癫痫患儿,依据随机数字表随机分为观察组和对照组,每组各103例。对照组给予奥卡西平治疗,观察组在对照组基础上给予柴胡疏肝汤治疗,15 d为1个疗程,连续治疗2个疗程。比较两组患儿治疗后临床疗效、脑电波,及治疗前后炎症因子、认知功能及中医症状积分的变化情况。结果:观察组患儿总有效率95.15%(98/103),显著高于对照组78.64%(81/103)(χ^(2)=12.318,P <0.05)。观察组患儿脑电波正常46例(44.66%),显著高于对照组28例(27.18%)(χ^(2)=6.833,P <0.05);观察组患儿脑电波痫性放电18例(17.48%),显著低于对照组43例(41.75%)(χ^(2)=14.556,P <0.05)。治疗后,两组患儿NSE、TNF-α及IL-6水平显著低于治疗前,FIQ、PIQ及VIQ评分显著高于治疗前(P <0.05),且观察组上述指标改善情况优于对照组(P <0.05)。治疗后,两组患儿中医各症状积分均显著降低(P <0.05),且观察组低于对照组(P <0.05)。结论:柴胡疏肝汤在治疗癫痫患儿疗效显著,能够改善脑电波、降低炎症因子水平、提升认知功能,并改善中医临床症状。Objective:To investigate the effects of Chaihu Shugan Decoction on brain waves,inflammatory factors,and cognitive function in children with epilepsy of phlegm-qi stagnation type.Methods:A total of 206 children with epilepsy of phlegm-qi stagnation type meeting the inclusion criteria were randomly divided into an observation group and a control group,each with 103 cases,according to a random number table.The control group received oxcarbazepine treatment,while the observation group received Chaihu Shugan Decoction in addition to the treatment of the control group.Each treatment course lasted 15 days,and two courses were conducted consecutively.Clinical efficacy,brain wave outcomes,and changes in inflammatory factors,cognitive function,and Traditional Chinese Medicine(TCM)symptom scores before and after treatment were compared between the two groups.Results:The total effective rate was significantly higher in the observation group(95.15%,98/103)than in the control group(78.64%,81/103)(χ^(2)=12.318,P<0.05).Normal brain waves were observed in 46 cases(44.66%)in the observation group,significantly higher than the control group′s 28 cases(27.18%)(χ^(2)=6.833,P<0.05).Epileptiform discharges were observed in 18 cases(17.48%)in the observation group,significantly lower than the control group′s 43 cases(41.75%)(χ^(2)=14.556,P<0.05).After treatment,NSE,TNF-α,and IL-6 levels significantly decreased,while FIQ,PIQ,and VIQ scores significantly increased in both groups(P<0.05),with better improvements in the observation group(P<0.05).TCM symptom scores significantly decreased in both groups after treatment(P<0.05),with lower scores in the observation group compared to the control group(P<0.05).Conclusion:Chaihu Shugan Decoction has significant therapeutic effects in children with epilepsy,improving brain wave abnormalities,reducing inflammatory factor levels,enhancing cognitive function,and alleviating TCM clinical symptoms.

关 键 词：柴胡疏肝汤 痰气郁结 小儿癫痫 疗效 脑电波 

分 类 号：R277.7[医药卫生—中医学]