微创肺表面活性物质联合无创高频振荡通气治疗早产儿呼吸窘迫综合征的临床效果  

Clinical effect of less invasive pulmonary surfactant combined with noninvasive high-frequency oscillatory ventilation in the treatment of respiratory distress syndrome in preterm infants

作　　者：郑志凌 黄爱玲 李育文 张静雯 ZHENG Zhiling;HUANG Ailing;LI Yuwen;ZHANG Jingwen(Department of Pediatrics,Guangzhou Conghua District Maternity and Child Care Hospital,Guangdong Province,Guangzhou 510900,China)

机构地区：[1]广州市从化区妇幼保健院儿科,广东广州510900

出　　处：《妇儿健康导刊》2025年第1期65-68,73,共5页JOURNAL OF WOMEN AND CHILDREN'S HEALTH GUIDE

摘　　要：目的观察微创肺表面活性物质联合无创高频振荡通气治疗早产儿呼吸窘迫综合征(RDS)的临床效果。方法选取2022年1月至2024年4月广州市从化区妇幼保健院收治的40例RDS早产儿,采用随机数字表法将其分为对照组(20例,微创肺表面活性物质+经鼻持续正压通气治疗)和观察组(20例,微创肺表面活性物质+无创高频振荡通气治疗),比较两组临床疗效、血气指标、并发症、临床指标(机械通气时间、呼吸支持时间、呼吸暂停次数)。结果观察组临床疗效优于对照组(P<0.05)。两组治疗前动脉血二氧化碳分压(PaCO_(2))、动脉血氧分压(PaO_(2))、PaO_(2)/吸入氧浓度分数(FiO_(2))均无显著差异(P>0.05);治疗后,两组PaCO_(2)均低于治疗前,PaO_(2)、PaO_(2)/FiO_(2)均高于治疗前,且观察组PaCO_(2)低于对照组,PaO_(2)、PaO_(2)/FiO均高于对照组(P<0.05)。两组并发症总发生率无显著差异(P>0.05)。观察组的机械通气时间、呼吸支持时间短于对照组,呼吸暂停次数少于对照组(P<0.05)。结论微创肺表面活性物质联合无创高频振荡通气治疗早产儿RDS的效果显著,可改善血气指标,缩短机械通气时间、呼吸支持时间,减少呼吸暂停次数,值得推广。Objective To observe the clinical effect of less invasive pulmonary surfactant combined with noninvasive high-frequency oscillatory ventilation in the treatment of respiratory distress syndrome(RDS)in preterm infants.Methods A total of 40 preterm infants with RDS admitted to Guangzhou Conghua District Maternity and Child Care Hospital from January 2022 to April 2024 were selected and divided into control group(20 cases,less invasive pulmonary surfactant+nasal continuous positive airway pressure treatment)and observation group(20 cases,less invasive pulmonary surfactant+noninvasive high-frequency oscillatory ventilation treatment)by the random number table method.The clinical efficacy,blood gas indexes,complications,clinical indexes(mechanical ventilation time,respiratory support time,apnea times)were compared between the two groups.Results The clinical effect of the observation group was better than that of the control group(P<0.05).There were no significant differences in arterial partial pressure of carbon dioxide(PaCO_(2)),arterial partial pressure of oxygen(PaO_(2)),and PaO_(2)/fraction of inspiration oxygen(FiO_(2))before treatment between the two groups(P>0.05).After treatment,the PaCO_(2)in both groups was lower than that before treatment,the PaO_(2)and PaO_(2)/FiO_(2)in both groups were higher than those before treatment(P<0.05),and the PaCO_(2)in the observation group was lower than that in the control group,the PaO_(2)and PaO_(2)/FiO_(2)in the observation group were higher than those in the control group(P<0.05).There was no significant difference in the incidence of complications between the two groups(P>0.05).The mechanical ventilation time and respiratory support time of observation group were shorter than those of control group,and the number of apnea was fewer than that of control group(P<0.05).Conclusion Less invasive pulmonary surfactant combined with noninvasive high-frequency oscillatory ventilation in the treatment of RDS in preterm infants has a significant effect,which can improve the blood

关 键 词：早产儿 呼吸窘迫综合征 微创肺表面活性物质 无创高频振荡通气 

分 类 号：R722.6[医药卫生—儿科]