脑组织氧饱和度与新生儿呼吸窘迫综合征严重程度及预后的关系  

Relationship between regional cerebral oxygen saturation and severity and prognosis of neonatal respiratory distress syndrome

作　　者：程可萍 陈卫圆 卢君 周子凯 CHENG Keping;CHEN Weiyuan;LU Jun;ZHOU Zikai(Department of Pediatrics,Yongkang Maternal and Child Health Hospital,Zhejiang Province,Yongkang 321399,China)

机构地区：[1]浙江省永康市妇幼保健院儿科,浙江永康321399

出　　处：《妇儿健康导刊》2025年第1期190-194,共5页JOURNAL OF WOMEN AND CHILDREN'S HEALTH GUIDE

基　　金：浙江省金华市第一批重大(重点)科技计划项目(2022-3-052)。

摘　　要：目的探讨脑组织氧饱和度(rSO_(2))与新生儿呼吸窘迫综合征(NRDS)严重程度及预后的关系。方法选取永康市妇幼保健院2021年6月至2022年12月诊断为NRDS的120例患儿作为观察组,并选取新生儿科同期出生的100例健康新生儿作为对照组。根据NRDS严重程度分为轻度组(34例)、中度组(59例)和重度组(27例);根据NRDS患儿预后情况分为预后良好组(79例)及预后不良组(41例)。比较各组rSO_(2)水平,采用Spearman相关性分析rSO_(2)与NRDS严重程度的关系,采用受试者工作特征(ROC)曲线分析rSO_(2)对NRDS预后的预测价值。结果观察组rSO_(2)低于对照组(P<0.05)。轻度组rSO_(2)最高,其次为中度组,重度组最低(P<0.001)。rSO_(2)与NRDS严重程度呈负相关(r=-0.672,P<0.001)。预后良好组rSO_(2)高于预后不良组(P<0.05)。ROC曲线分析显示,rSO_(2)预测NRDS预后的曲线下面积为0.877,灵敏度与特异度分别为92.68%、74.68%。结论rSO_(2)可作为评估NRDS严重程度及预后的重要指标之一。在NRDS治疗中,应积极监测rSO_(2),及时调整治疗方案,以提高患儿rSO_(2),改善其预后。Objective To investigate the relationship between regional cerebral oxygen saturation(rSO_(2))and the severity and prognosis of neonatal respiratory distress syndrome(NRDS).Methods A total of 120 neonates diagnosed with NRDS in Yongkang Maternal and Child Health Hospital from June 2021 to December 2022 were selected as the observation group,and 100 healthy neonates born in the Department of Neonatology during the same period were selected as the control group.According to the severity of NRDS,the neonates were divided into mild group(34 cases),moderate group(59 cases)and severe group(27 cases).According to the prognosis of NRDS,the neonates were divided into good prognosis group(79 cases)and poor prognosis group(41 cases).The rSO_(2)levels were compared among all groups,and the correlation between rSO_(2)and NRDS severity was analyzed by Spearman correlation analysis.The predictive value of rSO_(2)in NRDS prognosis was analyzed by receiver operating characteristic(ROC)curve.Results The rSO_(2)of the observation group was lower than that of the control group(P<0.05).The rSO_(2)was the highest in mild group,followed by moderate group,and the lowest in severe group(P<0.001).The rSO_(2)was negatively correlated with the severity of NRDS(r=-0.672,P<0.001).The rSO_(2)in the good prognosis group was higher than that in the poor prognosis group(P<0.05).ROC curve analysis showed that the area under the curve of rSO_(2)for predicting the prognosis of NRDS was 0.877,and the sensitivity and specificity were 92.68%and 74.68%,respectively.Conclusion The rSO_(2)can be used as one of the important indicators to evaluate the severity and prognosis of NRDS.In the treatment of NRDS,rSO_(2)should be actively monitored and adjust treatment to improve the rSO_(2) of children,and improve their prognosis.

关 键 词：脑组织氧饱和度 新生儿呼吸窘迫综合征 病情严重程度 预后 

分 类 号：R722.1[医药卫生—儿科]