Genetic insights in infectious diseases:Insights from a case report and implications for personalized medicine  

作　　者：Suryasnata Bhowmik Adrija Hajra Dhrubajyoti Bandyopadhyay 

机构地区：[1]Department of Medicine,Nilratan Sircar Medical College,Kolkata 700156,West Bengal,India [2]Department of Medicine,Brigham and Women’s Hospital/Mass General Brigham,Boston,MA 02115,United States [3]Department of Cardiovacular Imaging,Massachusetts General Hospital,Harvard Medical School,Boston,MA 02114,United States

出　　处：《World Journal of Clinical Cases》2025年第13期1-6,共6页世界临床病例杂志(英文)

摘　　要：The relationship between genetics and infectious diseases is important in shaping our understanding of disease susceptibility,progression,and treatment.Recent research shows the impact of genetic variations,such as heme-oxygenase promoter length,on diseases like malaria and sepsis,revealing both protective and inconclusive effects.Studies on vaccine responses highlight genetic markers like human leukocyte antigens,emphasizing the potential for personalized immunization strategies.The ongoing battle against drug-resistant tuberculosis(TB)illustrates the complexity of genomic variants in predicting resistance,highlighting the need for integrated diagnostic tools.Additionally,genome-wide association studies reveal antibiotic resistance mechanisms in bacterial genomes,while host genetic polymorphisms,such as those in solute carrier family 11 member 1 and vitamin D receptor,demonstrate their role in TB susceptibility.Advanced techniques like metagenomic next-generation sequencing promise detailed pathogen detection but face challenges in cost and accessibility.A case report involving a highly virulent Mycobacterium TB strain with the pks1 gene further highlights the need for genetic insights in understanding disease severity and developing targeted interventions.This evolving landscape emphasizes the role of genetics in infectious diseases,while also addressing the need for standardized studies and accessible technologies.

关 键 词：Genetic profiling Infectious diseases Tuberculosis virulence pks1 gene Genetic polymorphisms Personalized medicine 

分 类 号：R51[医药卫生—内科学] R446[医药卫生—临床医学]