Clinical significance of Ki-67 in patients with lung adenocarcinoma in situ complicated by type 2 diabetes  

作　　者：Ke Chen Ge Wang Jing-Cheng Hu Ying-Yi Zhou Hai-Tao Ma 

机构地区：[1]Department of Thoracic Surgery,The First Affiliated Hospital of Soochow University,Suzhou 215000,Jiangsu Province,China [2]Department of Endocrine,The First Affiliated Hospital of Soochow University,Suzhou 215000,Jiangsu Province,China

出　　处：《World Journal of Diabetes》2025年第2期114-122,共9页世界糖尿病杂志(英文)

摘　　要：BACKGROUND The increasing number of type 2 diabetes mellitus(T2DM)patients leads to higher rates of morbidity and mortality related to lung cancer.AIM To investigate the utility of the proliferating cell nuclear antigen Ki-67 in patients with lung adenocarcinoma in situ(AIS)complicated by T2DM.METHODS One hundred patients with AIS and T2DM(group A),100 patients with AIS alone(group B),and 60 patients with benign lung lesions(group C)admitted to the Department of Thoracic Surgery and Endocrinology of the First Affiliated Hospital of Soochow University from November 2021 to December 2022 were enrolled.Ki-67 expression was compared among the groups.RESULTS Group A had significantly higher levels of fasting plasma glucose(FPG),total cholesterol(TC),total triglyceride,low-density lipoprotein cholesterol,glycosylated hemoglobin(HbA1c),and insulin than groups B and C(P<0.01).Meanwhile,group B had higher insulin levels than group C(P<0.01).Group A exhibited a significantly higher average Ki-67 positivity rate than group B(P<0.01).The Ki-67 positivity rate in group A was 86.87%,while the positivity rate in group B was 77%.Ki-67 was positively correlated with FPG(P<0.01)and HbA1c levels(P<0.01).Ki-67,FBG,insulin,HbA1c,high-density lipoprotein cholesterol and TC were independent factors for patients with AIS complicated by T2DM.Chen K et al.Ki67 in patients with AIS complicated by T2DM WJD https://www.wjgnet.com 2 February 15,2025 Volume 16 Issue 2 CONCLUSION Ki-67 expression was higher in patients with AIS complicated by T2DM than in patients with AIS alone.Therefore,detecting the Ki-67 level might assist in the diagnosis of AIS in patients with T2DM.

关 键 词：KI-67 Type 2 diabetes mellitus Lung adenocarcinoma in situ IMMUNOHISTOCHEMISTRY Prognostic marker 

分 类 号：R587.2[医药卫生—内分泌]