中药天然产物调控Nrf2信号通路防治阿尔茨海默病的研究进展  

Research advancement of natural products of traditional Chinese medicine in regulating Nrf2 signaling pathway for prevention and treatment of Alzheimer's disease

作　　者：孙兴华[1,2] 曲阳 刘冬雪 王佳婧 张思琪 张淼[1,2] SUN Xinghua;QU Yang;LIU Dongxue;WANG Jiajing;ZHANG Siqi;ZHANG Miao(Key Laboratory of Acupuncture and Medicine Combination Prevention and Treatment of Major Brain Diseases in Heilongjiang Province,Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China;Department of Clinical Research,the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150001,China)

机构地区：[1]黑龙江中医药大学黑龙江省针药结合防治重大脑病重点实验室,黑龙江哈尔滨150040 [2]黑龙江中医药大学附属第二医院临床研究部,黑龙江哈尔滨150001

出　　处：《药物评价研究》2024年第12期2924-2936,共13页Drug Evaluation Research

基　　金：国家自然科学基金资助项目(82174509);黑龙江省自然科学基金资助项目(LH2023H066);黑龙江省“双一流”建设学科协同创新成果建设项目(1504123008)。

摘　　要：阿尔茨海默病(AD)是一种复杂且与年龄相关的进行性神经退行性疾病,是最常见的痴呆症类型,其特征是认知功能、语言和行为缺陷逐渐恶化。β-淀粉样蛋白(Aβ)异常沉积、神经原纤维缠结(NFT)、低水平乙酰胆碱、钙离子稳态失衡、氧化应激、神经炎症等被认为在AD的发病机制中起着关键作用。核因子E2相关因子2(Nrf2)是一种重要的转录调节因子,在氧化还原稳态、蛋白质降解、DNA修复以及调节外源代谢和免疫反应中发挥多种作用,已成为炎症、肿瘤治疗等领域研究的主要靶点,在AD的防治方面已被广泛关注。中药天然产物在AD防治过程中发挥着不可替代的作用。基于此,对Nrf2与AD的关系及中药天然产物调控Nrf2信号通路防治AD的机制进行总结归纳,以期为AD的治疗及新药开发提供参考。Alzheimer's disease(AD)is a complex and age-related progressive neurodegenerative disorder,the most common form of dementia,characterized by the progressive deterioration of cognitive function,language,and behavioral deficits.Abnormal deposition of beta amyloid protein(Aβ),neurofibrillary tangles(NFT),low levels of acetylcholine,Calcium ion steady-state imbalance,oxidative stress,and neuroinflammation are believed to play key roles in the pathogenesis of AD.Nrf2 is a significant transcriptional regulator that plays multiple roles in redox homeostasis,protein degradation,DNA repair,regulation of exogenous metabolism,and immune response.Nrf2 has emerged as a major target in the fields of inflammation and tumor therapy and has received extensive attention in the prevention and treatment of AD.The natural products of Chinese medicine play an irreplaceable role in the prevention and treatment of AD.Based on this,summarize and generalize the relationship between Nrf2 and AD,as well as the mechanism of regulating the Nrf2 signaling pathway by natural Chinese medicine products to prevent and treat AD,in order to provide reference for the treatment of AD and the development of new drugs.

关 键 词：阿尔茨海默病 天然产物 核因子E2相关因子2 氧化应激 炎症 

分 类 号：R285.5[医药卫生—中药学]