磁共振引导立体定向放疗靶区运动管理及不良反应研究进展  

Research progress in target motion management and toxicity of MR-guided stereotactic body radiation therapy

作　　者：张萌林 刘敏[2] 李益民 郎锦义[2] 阴骏 Zhang Menglin;Liu Min;Li Yimin;Lang Jinyi;Yin Jun(College of Clinical Medicine,North Sichuan Medical College,Nanchong637000,China;Department of Radiation Oncology,Affiliated Cancer Hospital of University of Electronic Science and Technology of China,Radiation Oncology Key Laboratory of Sichuan Province,Sichuan Clinical Research Center for Cancer,Sichuan Cancer Hospital&Institute,Sichuan Cancer Center,Chengdu610041,China)

机构地区：[1]川北医学院临床医学院,南充637000 [2]电子科技大学附属肿瘤医院放疗科,放射肿瘤学四川省重点实验室,四川省肿瘤临床医学研究中心,四川省肿瘤医院研究所,四川省癌症防治中心,成都610041

出　　处：《中华放射肿瘤学杂志》2025年第1期36-43,共8页Chinese Journal of Radiation Oncology

基　　金：四川省科技计划项目(2021YFS0227);北京市希思科-再鼎肿瘤治疗研究基金项目(Y-zai2021/qn-0005);四川省自然科学基金面上项目(2023NSFSC0711)。

摘　　要：立体定向放射治疗是治疗肿瘤的重要手段,然而肿瘤的分次运动、图像引导的分辨率以及是否采用自适应技术是影响立体定向放射治疗精准性的重要因素。不同的图像引导方式和运动管理方案对放射治疗相关不良反应的控制呈现出不同程度的差异。随着MR加速器开始投入临床使用,其优异的软组织成像对比度、自适应放疗技术以及对运动的靶区实时的运动管理能否为患者带来更好的不良反应控制,目前仍没有确切的结论。因此,本文就MR加速器在减轻放射治疗相关不良反应的优势、临床应用和目前已报道的治疗后不良反应进行综述。Stereotactic radiation therapy is a crucial approach in the treatment of tumors.However,the precision of stereotactic radiation therapy is influenced by important factors such as fractional tumor motion,image-guided resolution,and the utilization of adaptive techniques.Different image-guided methods and motion management strategies exhibit varying degrees of control over radiation-related toxicity.With the clinical application of magnetic resonance accelerator,it is still unclear whether its excellent soft tissue imaging contrast,adaptive radiotherapy technology,and real-time motion management of the moving target can bring better toxicity control for patients.Hence,the advantages of magnetic resonance accelerator in mitigating radiation-related toxicity,its clinical applications,and the reported post-treatment toxic reactions were comprehensively reviewed in this article.

关 键 词：放射疗法 磁共振引导放射疗法 分次运动 立体定向放射疗法 放射治疗相关不良反应 

分 类 号：R445.2[医药卫生—影像医学与核医学] R730.55[医药卫生—诊断学]