住院患者早期静脉转口服治疗的成本节约分析  

Cost-saving analysis evaluating early switch from intravenous to oral therapy among hospitalized patients

作　　者：戴婷婷 曾双双[1,2,3] 朱敏文 黄琪[1,2,3] 肖笛 尹桃[1,2,3] 张蕊萍 刘韶[1,2,3] DAI Tingting;ZENG Shuangshuang;ZHU Minwen;HUANG Qi;XIAO Di;YIN Tao;ZHANG Ruiping;LIU Shao(Department of Pharmacy,Xiangya Hospital,Central South University,Hunan Changsha 410008,China;Clinical Pharmacology Research Center of Hunan Province,Hunan Changsha 410008,China;National Clinical Medical Research Center for Geriatric Diseases(Xiangya),Hunan Changsha 410008,China;First Affiliated Hospital,Hunan University of Chinese Medicine,Hunan Changsha 410004,China)

机构地区：[1]中南大学湘雅医院药学部,湖南长沙410008 [2]湖南省临床药学研究中心,湖南长沙410008 [3]国家老年疾病临床医学研究中心(湘雅),湖南长沙410008 [4]湖南中医药大学第一附属医院,湖南长沙410004

出　　处：《中国医院药学杂志》2024年第24期2876-2880,共5页Chinese Journal of Hospital Pharmacy

基　　金：湖南省自然科学基金资助项目(编号:2021JJ80019);国家老年疾病临床医学研究中心临床研究基金项目(编号:2021LNJJ20);国家卫生健康委医院管理研究所医院药学高质量发展研究项目(编号:NTHAYS2311)。

摘　　要：目的:确定符合静脉转口服标准但未进行转换的可转换率,并明确静脉转口服药物的成本节约情况。方法:通过横断面研究,以简单随机整群抽样的方法,获取2023年3月1日至2024年3月1日期间住院的患者及医嘱信息。以静脉和口服药品间差价、可转换剂次、总静脉给药剂次3个要素为统计指标,计算目标药物符合静脉转口服标准但未进行转换的比例和药物成本的节约值。结果:针对5种目标药物,共纳入20043名患者,患者主要分布在内科病房。5种目标药物静脉转口服的可转换率平均值为52.44%。5种目标药物年潜在节约成本为6921009.62元,平均每位患者可潜在节约335.3元/年。结论:住院患者中符合静脉转口服标准但未进行转换的药品比例较高,静脉转口服策略可大量节约药物治疗成本。建议在条件允许的情况下,对于符合静脉转口服标准的患者尽量使用口服药物。OBJECTIVE To determine the conversion rate fulfilling the standard of intravenous oral dosing without conversion and clarify the cost-saving status of intravenous oral dosing.METHODS For this cross-sectional study,the prescriptions of inpatients from March 1,2023 to March 1,2024 was obtained by simple random cluster sampling.Price differences between intravenous and oral drugs,number of convertible drugs and total number of intravenous drugs were adopted as statistical indicators.The proportion of target drugs fulfilling the standard of intravenous drugs without conversion and saving value of drug cost were calculated.RESULTS A total of 20043 patients were largely distributed at internal medicine wards.The average conversion rate of five target drugs from intravenous to oral dosing was 52.44%.Annual potential cost-saving of five target drugs was 6921009.62 yuan and average potential cost saving per patient 335.3 yuan/year.CONCLUSION The proportion of drugs fulfilling the standard of intravenous oral dosing without conversion remains high.The strategy of intravenous oral dosing may greatly save the costs of medication.Therefore oral drugs should be utilized as much as possible for patients fulfilling the standard of intravenous oral dosing when conditions permit.

关 键 词：静脉转口服 药物经济学 最小成本分析 住院患者 

分 类 号：R956[医药卫生—药学]