1型糖尿病认知功能障碍的研究进展  

Research progress of cognitive dysfunction in type 1 diabetes mellitus

作　　者：滑文婷 李晓涛 田利民[1,2] HUA Wenting;LI Xiaotao;TIAN Limin(The First School of Clinical Medicine,Lanzhou University,Lanzhou 730000,China;Department of Endocrinology,Sichuan Provincial People's Hospital,Chengdu 610072,China;Department of Endocrinology,Gansu Provincial Hospital,Lanzhou 730000,China)

机构地区：[1]兰州大学第一临床医学院,甘肃兰州730000 [2]四川省人民医院内分泌科,四川成都610072 [3]甘肃省人民医院内分泌科,甘肃兰州730000

出　　处：《分子影像学杂志》2025年第1期114-119,共6页Journal of Molecular Imaging

基　　金：甘肃省科技重大专项(22ZD6FA033)。

摘　　要：随着1型糖尿病(T1DM)发病率的增加以及患者预期寿命的延长,T1DM相关脑损伤及其引起的认知功能异常越来越受到关注。已有多项研究表明T1DM与认知功能障碍相关。近年来,MRI技术的广泛应用为探索T1DM相关脑损伤的神经病理生理机制提供了客观的影像学证据。本文围绕T1DM患者认知功能障碍的表现、MRI技术在研究其脑损伤中的应用以及潜在的病理机制进行综述,通过对既往研究进行归纳总结,旨在帮助临床医生深入理解T1DM与认知功能障碍的关系,为未来的研究提供新的视角,以期早期识别和干预T1DM患者认知功能障碍。Type 1 diabetes mellitus(T1DM)-related cognitive dysfunction and potential brain impairment have attracted increasing attention with the rising incidence of T1DM and the extension of patient life expectancy.Several studies have demonstrated an association between T1DM and cognitive dysfunction.In recent years,the widespread application of MRI technology has provided objective imaging evidence for exploring the neuropathophysiological mechanisms of brain impairment in T1DM.This article reviews the manifestations of cognitive dysfunction,the application of MRI technology in brain impairment,and the underlying pathological mechanism in patients with T1DM.By summarizing previous research,it aims to help clinicians gain a deeper understanding of the relationship between T1DM and cognitive dysfunction,and to provide new perspectives for future research,with the hope of early identification and intervention for cognitive dysfunction in patients with T1DM.

关 键 词：1型糖尿病 认知障碍 磁共振成像 

分 类 号：R587.2[医药卫生—内分泌] R749.1[医药卫生—内科学] R445.2[医药卫生—临床医学]