介孔二氧化硅材料的药学应用进展  

Progress in Pharmaceutical Applications of Mesoporous Silica Materials

作　　者：闫洁 顾丰华 YAN Jie;GU Fenghua(State Key Lab.of New Drug and Pharmaceutical Process,China State Institute of Pharmaceutical Industry,Shanghai 200437;Shanghai Technical Service Platform for Biological Material Druggability Evaluation,Shanghai 200437)

机构地区：[1]中国医药工业研究总院创新药物与制药工艺国家重点实验室,上海200437 [2]上海市生物物质成药性评价技术服务平台,上海200437

出　　处：《中国医药工业杂志》2024年第12期1628-1633,共6页Chinese Journal of Pharmaceuticals

摘　　要：介孔二氧化硅纳米颗粒(MSNs)具有可调节的孔径和孔结构、高比表面积、良好的生物相容性,作为递送载体可提高药物稳定性、实现药物控释、改善难溶性药物的溶解和生物利用度。文章总结了MSNs作为药物载体的优势,综述了MSNs近年来在药物递送、疾病治疗中的应用,并展望了MSNs的应用前景。Mesoporous silica nanoparticles(MSNs)have adjustable pore diameters and pore structures,high specific surface areas,as well as good biocompatibility.As a delivery carrier,MSNs can enhance drug stability,realize the controlled release of drugs,and improve the solubility and bioavailability of poorly soluble drugs.This review summarizes the advantages of MSNs as drug carriers,introduces the applications of MSNs in drug delivery and disease treatment in recent years,and anticipates the application prospects of MSNs.

关 键 词：介孔二氧化硅纳米颗粒 药物递送 肿瘤治疗 神经退行性疾病 研究进展 

分 类 号：TQ127.2[化学工程—无机化工] R944.9[医药卫生—药剂学]