吲哚类生物碱的生物活性研究进展  

Research progress on biological activity of indole alkaloid

作　　者：古虹 李俊辉 庞茗月 陈坤 张成义 GU Hong;LI Junhui;PANG Mingyue;CHEN Kun;ZHANG Chengyi(Dazhou Vocational College of Traditional Chinese Medicine,Dazhou,Sichuan 635000,China;College of Pharmacy,Beihua University,Jilin,Jilin 132013,China;不详)

机构地区：[1]达州中医药职业学院,四川达州635000 [2]北华大学药学院,吉林吉林132013 [3]不详

出　　处：《现代医药卫生》2025年第1期181-186,共6页Journal of Modern Medicine & Health

基　　金：吉林省科技发展计划项目(20190304048YY)。

摘　　要：吲哚是一种具有特殊骨架结构和突出功能的杂环化合物,根据不同的作用机制发挥其广泛的药理活性。该文根据吲哚类生物碱,如螺环吲哚、桥环吲哚等化学结构的不同,对近4年来的最新研究进展展开论述,包括吲哚类生物碱的药理活性、结构-活性关系、作用机制等,期望为设计新型吲哚类药物方面的研究提供参考价值。Indole is a heterocyclic compound with special structure and prominent function,which exerts its extensive pharmacological activities according to different action mechanisms.According to the different chemical structures of indole alkaloids,such as spiro indole and bridged indole,this paper reviewed the latest research progress in recent four years,including pharmacological activities,structure-activity relationship and mechanism of action of indole alkaloids.The information compiled in this paper can provide reference value for the design of new indole drugs.

关 键 词：螺环吲哚 桥环吲哚 杂环 生物活性 综述 

分 类 号：O626[理学—有机化学]