中药调控Wnt/β-catenin信号通路干预糖尿病溃疡的研究进展  

Research Progress of Chinese Medicine Regulating Wnt/β-catenin Signaling Pathway in the Intervention of Diabetic Ulcer

作　　者：党赢 董重阳[1] 刘钰[2] 吴昊[1] 海日[1] 白洁[1] 焦雨琦 师建平[1] DANG Ying;DONG Chongyang;LIU Yu;WU Hao;HAI Ri;BAI Jie;JIAO Yuqi;SHI Jianping(Inner Mongolia Medical College,Hohhot 010110 Inner Mongolia,China;Hunan University of Chinese Medicine,Changsha 410208 Hunan,China)

机构地区：[1]内蒙古医科大学,内蒙古呼和浩特010110 [2]湖南中医药大学,湖南长沙410208

出　　处：《中药新药与临床药理》2025年第1期146-151,共6页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：国家自然科学基金地区项目(82460899);国家自然科学基金青年项目(82205127);内蒙古自治区高等教育科学研究项目(NJZY23131);内蒙古自治区草原英才团队滚动支持项目(CYCTD2024017);内蒙古自然科学基金面上项目(2019MS08162,2022MS08022)。

摘　　要：糖尿病溃疡是一种常见的糖尿病并发症,严重影响糖尿病患者的生活质量和预后。研究发现Wnt/β-catenin通路能通过调控细胞自噬、细胞凋亡、血管新生和氧化应激等多种生物过程,影响糖尿病溃疡创面愈合的进程。中药有多途径、多机制、多靶点的作用特点,能够通过调控Wnt/β-catenin信号通路促进糖尿病溃疡的创面愈合。该文系统概括了Wnt/β-catenin信号通路在糖尿病溃疡创面愈合中的作用机制及中医药干预作用的研究进展,以期为促进中医药防治糖尿病溃疡创面愈合研究提供新方向。Diabetic ulcer is a common complication of diabetes,which seriously affects the quality of life and prognosis of diabetic patients.It has been found that Wnt/β-catenin pathway can affect the wound healing process of diabetic ulcer by regulating many biological processes such as autophagy,apoptosis,angiogenesis and oxidative stress.Chinese medicine has the characteristics of multi-pathways,multi-mechanism and multi-targets,which can promote wound healing of diabetic ulcer by regulating Wnt/β-catenin signaling pathway.In this paper,the mechanism of Wnt/β-catenin signaling pathway in wound healing of diabetic ulcer and the research progress on the intervention effect of traditional Chinese medicine were systematically summarized.Our aim is to provide a new direction for traditional Chinese medicine to promote diabetic ulcer wound healing.

关 键 词：糖尿病溃疡 创面愈合 WNT/Β-CATENIN信号通路 中药 综述 

分 类 号：R587.1[医药卫生—内分泌]