江西省0~6岁学龄前儿童呼吸道合胞病毒肺炎临床特点以及诱发重症感染的危险因素分析  

Clinical characteristics of respiratory syncytial virus pneumonia and analysis of risk factors for severe infection in preschool children aged 0-6 years in Jiangxi Province

作　　者：丁莲富 刘洪[1] 杨弋仙 危艺臻 熊吕平 梁振山[3] 易鹏飞[4] 李青[1] DING Lian-fu;LIU Hong;YANG Yixian(Department of Emergency,Jiangxi Provincial Children's Hospital,Nanchang 330006,China)

机构地区：[1]江西省儿童医院急诊科,330006 [2]江西省儿童医院综合病房,330006 [3]江西省儿童医院检验科,330006 [4]江西省儿童医院药学部,330006

出　　处：《中国现代药物应用》2025年第1期34-37,共4页Chinese Journal of Modern Drug Application

基　　金：江西省中医药管理局科技项目(项目编号:2022B079)。

摘　　要：目的描述江西省0~6岁学龄前儿童呼吸道合胞病毒(RSV)肺炎的临床特点,并分析诱发重症感染的危险因素。方法选取0~6岁学龄前RSV肺炎患儿361例,根据RSV肺炎的严重程度分为重症组(101例)和普通组(260例)。对比两组患儿的临床资料,分析诱发0~6岁学龄前儿童RSV肺炎重症感染的危险因素。结果纳入的0~6岁学龄前RSV肺炎患儿好发年龄在3岁以下,以男性患儿常见,平均体温在39℃左右,肺部的影像学表现以点片状影为主。重症组患儿的入院前病程(6.86±1.78)d长于普通组的(5.85±1.89)d,入院时白细胞计数(13.87±1.98)×10^(9)/L、入院时中性粒细胞百分比(46.60±20.85)%、入院时C反应蛋白(7.89±2.34)mg/L高于普通组的(9.89±1.76)×10^(9)/L、(39.12±19.26)%、(5.89±2.12)mg/L,入院时淋巴粒细胞百分比(42.33±19.05)%低于普通组的(48.76±18.31)%,存在统计学差异(P<0.05)。Logistic回归分析结果显示:入院前病程长、入院时C反应蛋白高、入院时白细胞计数高为诱发0~6岁学龄前儿童RSV肺炎重症感染的独立危险因素(OR=4.685、2.634、3.967,P<0.05)。结论入院前病程长、入院时C反应蛋白高、入院时白细胞计数高是诱发0~6岁学龄前儿童重症感染的独立危险因素,对于RSV肺炎患儿,应该早发现早治疗,才能避免发展为重症感染。Objective To describe the clinical characteristics of respiratory syncytial virus(RSV)pneumonia in preschool children aged 0-6 years in Jiangxi Province,and analyze the risk factors for severe infection.Methods 361 preschool children aged 0-6 years with RSV pneumonia were divided into severe group(101 cases)and general group(260 cases)based on the severity of RSV pneumonia.The clinical data of the two groups were compared,and the risk factors inducing severe RSV pneumonia infection in preschool children aged 0-6 years were analyzed.Results The prevalence of RSV pneumonia in preschool children aged 0-6 years included was below 3 years old,and it was common in male children,with a mean temperature of 39℃.The imaging manifestations of the lungs were predominantly punctate and lamellar shadows.The duration of disease before admission of(6.86±1.78)d in the severe group was longer than(5.85±1.89)d in the general group;in the severe group,the white blood cell count at admission was(13.87±1.98)×10^(9)/L,the percentage of neutrophils at admission was(46.60±20.85)%,and the C-reactive protein at admission was(7.89±2.34)mg/L,which were higher than(9.89±1.76)×10^(9)/L,(39.12±19.26)%,and(5.89±2.12)mg/L in the general group;the percentage of lymphogranulocyte of(42.33±19.05)%at admission in the severe group was lower than(48.76±18.31)%in the general group;there were statistical differences(P<0.05).Logistic regression analysis showed that long duration of disease before admission,high C-reactive protein at admission,and high white blood cell count at admission were independent risk factors for severe infection of RSV pneumonia in preschool children aged 0-6 years(OR=4.685,2.634,3.967;P<0.05).Conclusion The long duration of disease before admission,high C-reactive protein at admission,and high white blood cell count at admission are the independent risk factors for severe infection in preschool children aged 0-6 years.Early detection and timely treatment of children with RSV pneumonia are crucial to prevent the prog

关 键 词：呼吸道合胞病毒肺炎 学龄前儿童 重症感染 预后 

分 类 号：R725.6[医药卫生—儿科]