小儿荆杏止咳颗粒联合特布他林治疗小儿急性支气管炎疗效观察及对肺通气功能的影响  

Observation on Curative Effect of Xiao'er Jingxing Zhike Granules Combined with Terbutaline on Acute Bronchitis in Children and Its Impact on Lung Ventilation Function

作　　者：杨静[1] 朱萍[1] 王书举[1] YANG Jing;ZHU Ping;WANG Shuju(Pediatric Respiratory Department,Nanyang Central Hospital,Nanyang Henan 473000,China)

机构地区：[1]南阳市中心医院儿童呼吸科,河南南阳473000

出　　处：《新中医》2025年第2期86-90,共5页New Chinese Medicine

摘　　要：目的:观察小儿荆杏止咳颗粒联合特布他林治疗急性支气管炎患儿的临床疗效及对肺通气功能的影响。方法:选择2021年6月—2023年6月南阳市中心医院收治的急性支气管炎患儿126例,按照随机数字表法分为治疗组与对照组各63例。对照组给予硫酸特布他林雾化吸入用溶液治疗,治疗组在对照组基础上联合小儿荆杏止咳颗粒治疗。比较2组总有效率、中医证候评分、肺通气功能指标[潮气量(TV)、达峰时间比(TPTEF/TE)、呼吸频率(RR)]、炎症因子[C-反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)]水平及不良反应发生情况。结果:治疗后,治疗组总有效率为96.83%(61/63),对照组为80.95%(51/63),2组比较,差异有统计学意义(P<0.05)。治疗后,2组中医证候评分均较治疗前下降(P<0.05),且治疗组评分低于对照组(P<0.05)。治疗后,2组TV、TPTEF/TE水平较治疗前升高(P<0.05),RR水平较治疗前下降(P<0.05);且治疗组TV、TPTEF/TE水平高于对照组(P<0.05),RR水平低于对照组(P<0.05)。治疗后,2组CRP、TNF-α水平均较治疗前降低(P<0.05),且治疗组CRP、TNF-α水平低于对照组(P<0.05)。治疗组不良反应发生率为4.76%(3/63),对照组为12.70%(8/63),2组比较,差异无统计学意义(P>0.05)。结论:小儿荆杏止咳颗粒联合特布他林治疗急性支气管炎患儿可提高临床疗效,下调炎症因子水平,有效改善患儿中医证候及肺功能,且不良反应相对较少。Objective:To observe the clinical effect of Xiao'er Jingxing Zhike Granules combined with Terbutaline on children with acute bronchitis and its impact on lung ventilation function.Methods:A total of 126 cases of children with acute bronchitis admitted to Nanyang Central Hospital from June 2021 to June 2023 were selected and divided into the treatment group and the control group according to the random number table method,with 63 cases in each group.The control group was treated with Terbutaline Sulfate Nebuliser Solution,and the treatment group was treated with Xiao'er Jingxing Zhike Granules in addition to the control group's treatment.The total effective rates,traditional Chinese medicine(TCM)syndrome scores,lung ventilation function indicators[tidal volume(TV),time to peak tidal expiratory flow as a percentage of total expiratory time(TPTEF/TE),respiratory rate(RR)],levels of inflammatory markers[C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)],and adverse reactions were compared between the two groups.Results:After treatment,the total effective rate was 96.83%(61/63)in the treatment group and 80.95%(51/63)in the control group,with a significant difference between the two groups(P<0.05).After treatment,TCM syndrome scores in the two groups were decreased when compared with those before treatment(P<0.05),with the treatment group scoring lower than the control group(P<0.05).After treatment,the levels of TV and TPTEF/TE in the two groups were increased when compared with those before treatment(P<0.05),and RR levels were decreased when compared with those before treatment(P<0.05);the treatment group showed higher levels of TV and TPTEF/TE and lower RR level than the control group(P<0.05).After treatment,the levels of CRP and TNF-αin the two groups were reduced when compared with those before treatment(P<0.05),with the treatment group showing lower levels than the control group(P<0.05).The incidence of adverse reactions was 4.76%(3/63)in the treatment group and 12.70%(8/63)in the control group,with no sig

关 键 词：小儿急性支气管炎 小儿荆杏止咳颗粒 特布他林 肺功能 炎症因子 

分 类 号：R562.21[医药卫生—呼吸系统]