血清FT4、TSH水平联合检测在妊娠合并甲状腺功能减退症患者不良母婴结局诊断中的效能  

Efficiency of combined detection of serum FT4 and TSH levels in diagnosis of adverse maternal and infant outcomes in pregnant women with hypothyroidism

作　　者：华伟 HUA Wei(Department of Obstetrics and Gynecology of the First Affiliated Hospital of Nanyang Medical College,Nanyang 473000 Henan,China)

机构地区：[1]南阳医学高等专科学校第一附属医院妇产科,河南南阳473000

出　　处：《中国民康医学》2025年第2期116-118,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:分析血清游离甲状腺素(FT4)、促甲状腺激素(TSH)水平联合检测在妊娠合并甲状腺功能减退症(简称甲减)患者不良母婴结局诊断中的效能。方法:回顾性分析2021年9月至2023年10月该院收治的100例妊娠合并甲减患者的临床资料,设为观察组,回顾性分析同期于该院行常规产检的100名健康孕妇的临床资料,设为对照组。比较两组、不同母婴结局患者血清FT4、TSH水平,并绘制受试者工作特征(ROC)曲线,分析血清FT4、TSH水平单项及联合检测在妊娠合并甲减患者不良母婴结局诊断中的效能。结果:观察组血清FT4水平低于对照组,血清TSH水平高于对照组,差异均有统计学意义(P<0.05);不良母婴结局患者血清FT4水平低于良好母婴结局患者,血清TSH水平高于良好母婴结局患者,差异均有统计学意义(P<0.05);ROC曲线分析结果显示,血清FT4、TSH水平单项及联合检测诊断妊娠合并甲减患者不良母婴结局的曲线下面积(AUC)分别为0.827、0.761、0.941,其中联合检测的AUC高于二者单项检测。结论:血清FT4、TSH水平联合检测诊断妊娠合并甲减患者不良母婴结局的效能高于二者单项检测。Objective:To analyze efficiency of combined detection of serum free thyroxine(FT4)and thyroid stimulating hormone(TSH)levels in diagnosis of adverse maternal and infant outcomes in pregnant women with hypothyroidism.Methods:The clinical data of 100 pregnant women with hypothyroidism admitted to this hospital from September 2021 to October 2023 were retrospectively analyzed and they were set as the observation group.The clinical data of 100 healthy pregnant women who underwent routine prenatal examination in the hospital during the same period were retrospectively analyzed and they were set as the control group.The serum FT4 and TSH levels were compared between the two groups and among the patients with different maternal and infant outcomes.The receiver operating characteristic(ROC)curve was drawn to analyze the efficiencies of single and combined detection of serum FT4 and TSH levels in the diagnosis of adverse maternal and infant outcomes in the pregnant women with hypothyroidism.Results:The serum FT4 level in the observation group was lower than that in the control group,the serum TSH level was higher than that in the control group,and the differences were statistically significant(P<0.05).The serum FT4 level of the patients with adverse maternal and infant outcomes was lower than that of the patients with good maternal and infant outcomes,the serum TSH level was higher than that of the patients with good maternal and infant outcomes,and the differences were statistically significant(P<0.05).The ROC curve analysis showed that the area under the curve(AUC)of single and combined detection of serum FT4 and TSH levels in the diagnosis of adverse maternal and infant outcomes in the pregnant women with hypothyroidism was 0.827,0.761 and 0.941,separately,and the AUC of combined detection was higher than that of single detection.Conclusions:The efficiency of combined detection of serum FT4 and TSH levels in the diagnosis of adverse maternal and infant outcomes in the pregnant women with hypothyroidism is higher than t

关 键 词：妊娠 甲状腺功能减退症 游离甲状腺素 促甲状腺激素 不良母婴结局 诊断 

分 类 号：R714.25[医药卫生—妇产科学]