见光诱导催化合成3,4-二氢异喹啉-1(2H)-酮及其衍生物  

Visible light induced catalytic synthesis of 3,4-dihydroisoquinoline-1(2H)-ones

作　　者：康建军[1] 王津[1] 陈艳[1] KANG Jian-jun;WANG Jin;CHEN Yan(School of Pharmacy,Fujian Medical University,Fuzhou 350004,China)

机构地区：[1]福建医科大学药学院,福建福州350004

出　　处：《化学研究与应用》2025年第1期230-236,共7页Chemical Research and Application

摘　　要：建立了一种在温和条件下,用可见光催化合成一系列3,4-二氢异喹啉-1(2H)-酮及其衍生物的方法。该方法在室温条件下,以2-烯丙基-N-甲氧基苯甲酰胺为模板底物,以碘化钾作为光催化剂,25 W 460 nm的蓝色LED灯照射下,合成一系列3,4-二氢异喹啉-1(2H)-酮衍生物,最高产率可达到83%。该合成路径具有底物适用范围广、经济实用等特点,为3,4-二氢异喹啉-1(2H)-酮衍生物合成提供了一种经济简便的方法。A method was established to synthesis a series of 3,4-dihydroisoquinoline-1(2H)-one and its derivatives by visible photocatalysis under mild conditions.Under room temperature,this method used 2-allyl-N-methoxybenamide as the template substrate,potassium iodide as the photocatalyst,and irradiated under the blue LED lamp of 25 W 460 nm to synthesise a series of 3,4-dihydroisoquinoline-1(2H)-one derivatives,the highest yield could reach 83%.This synthesis pathway had the characteristics of wide substrate applicability and economic practicality,providing an economical and convenient method for the synthesis of 3-substituted3,4-dihydroisoquinoline-1(2H)-one derivatives.

关 键 词：可见光 2-烯丙基-N-甲氧基苯甲酰胺 3 4-二氢异喹啉-1(2H)-酮 异喹啉酮 

分 类 号：O626.4[理学—有机化学]