石河子女性AMH参考值的建立及与性激素的相关性  

Establishment of AMH reference values for women in Shihezi and their correlation with sex hormones

作　　者：周侃 张玉[1] 高丽敏[1,2] 刘旻 陈月婵[1] 王小沛[1] 王姣 ZHOU Kan;ZHANG Yu;GAO Limin;LIU Min;CHEN Yuechan;WANG Xiaopei;WANG Jiao(Department of Reproductive Medicine,The First Affiliated Hospital of Shihezi University,Shihezi,Xinjiang,832000,China; Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430030,China)

机构地区：[1]石河子大学第一附属医院生殖医学科,新疆石河子832000 [2]华中科技大学同济医学院,武汉430030

出　　处：《新疆医学》2024年第12期1448-1452,共5页Xinjiang Medical Journal

基　　金：石河子大学校级科研项目(项目编号:ZZZC2022063)

摘　　要：目的建立石河子育龄女性血清抗缪勒管激素(Anti-Müllerian Hormone,AMH)的参考区间。方法收集2020年1月-2023年6月于石河子大学第一附属医院生殖医学科健康查体的553例育龄女性为研究对象,采用化学发光免疫检测技术测定血清AMH及FSH、LH、E2、PROG、TESTO、PRL水平,按年龄分为6组,选取第5百分位数(P_(5))和第95百分位数(P_(95))作为AMH参考区间的上下限,分析血清AMH与年龄及性激素水平的相关性。结果育龄女性血清AMH水平随年龄的增加呈逐渐递减趋势;血清AMH参考区间范围分别是:19-24岁0.93-11.34 ng/ml、25-29岁0.78-10.67 ng/ml、30-34岁0.01-8.57 ng/ml、35-39岁0.01-6.00 ng/ml、40-44岁0.01-4.40 ng/ml、45-49岁0.01-1.05ng/ml。19-34岁年龄段女性血清AMH水平与LH呈正相关(p<0.05),与TESTO呈显著正相关(p<0.01);35-49岁年龄段女性血清AMH水平与E2水平呈正相关(p<0.05),与FSH及LH水平呈显著负相关(p<0.01);而AMH水平与PRL及PROG在各年龄段女性中均无相关性(p>0.05)。讨论建立石河子育龄女性血清AMH的参考区间,将其与性激素联合检测,有助于评估本地区育龄期女性的卵巢储备功能,也可为临床诊疗及预后判断、辅助生殖技术的实施提供参考依据。Objective To establish the reference intervals for serum Anti-Müllerian Hormone(AMH)in reproductive-age women in Shihezi.Methods A total of 553 women of reproductive age who were examined at the Department of Reproductive Medicine of the First Affiliated Hospital of Shihezi University from January 2020 to June 2023 were enrolled as study subjects.Serum levels of AMH and FSH,LH,E2,PROG,TESTO,PRL levels were determined using the chemiluminescent immunoassay technique,and participants were divided into six age groups.The 5th percentile(P_(5))and the 95th percentile(P_(95))were established as the upper and lower limits of the AMH reference interval,and the correlation between serum AMH,age,and sex hormone levels was analyzed.Results Serum AMH levels in women of childbearing age decreased with age gradually.The serum AMH reference intervals were 0.93-11.34 ng/mL for 19-24 years,0.78-10.67 ng/mL for 25-29 years,0.01-8.57 ng/mL for 30-34 years,0.01-6.00 ng/mL for 35-39 years,0.01-4.40 ng/mL for 40-44 years,0.01-1.05 ng/mL for 45-49 years.Serum levels of AMH were positively correlated with LH(P<0.05)and significant⁃ly positively correlated with TESTO(P<0.01)in women aged from 19 to 34 years;serum AMH levels were positively correlated with E2 levels(P<0.05)and significantly negatively correlated with FSH and LH levels(P<0.01)in women aged 35-49 years,while AMH levels were not correlated with PRL and PROG in women of all ages(P>0.05).Discussion Establishing a reference interval for serum AMH levels in women of childbearing age in Shihezi,and testing it alongside sex hormones,can aid in evaluating the ovarian reserve function of women in this region.This can also provide a foundational reference for clinical diagnosis and prognosis,as well as for the application of assisted reproductive technology.

关 键 词：AMH 性激素 年龄 育龄女性 

分 类 号：R711.75[医药卫生—妇产科学]