PCT、H-FABP、心肌酶谱联合hs-cTnT对心肌损伤的评估价值  

Evaluation and clinical value of PCT,H-FABP,myocardial enzyme combined with hs-cTnT for patients with myocardial injury

作　　者：阿孜古力·艾尔肯 AZIGULI Aierken(No.3 Department of Cardiology,Urumqi Friendship Hospital,Urumqi,830049,China)

机构地区：[1]乌鲁木齐市友谊医院心内三科,乌鲁木齐830049

出　　处：《新疆医学》2024年第11期1355-1359,共5页Xinjiang Medical Journal

摘　　要：目的探讨降钙素原(PCT)、心肌型脂肪酸结合蛋白(H-FABP)、心肌酶谱联合心肌超敏肌钙蛋白T(hs-cTnT)对冠心病患者心肌损伤程度的评估价值。方法本文为回顾性研究。选取2022年1月至2023年4月诊治的138例冠心病患者作为观察组,同期69例健康体检者为对照组,并根据心肌损伤程度分为轻度组(单支病变,n=92)和重度组(双支或三支病变,n=46),采用SPSS22.0软件对PCT、H-FABP、肌酸激酶同工酶(CK-MB)、肌酸激酶(CK)、hs-cTnT行独立样本t检验;采用SPSS22.0软件绘制PCT、H-FABP、CK-MB、CK、hs-cTnT受试者工作曲线分析其预测冠心病患者心肌损伤程度的曲线下面积(AUC)值、敏感度及特异度。结果观察组的PCT、H-FABP、CK-MB、CK、hs-cTnT均高于对照组,差异具有统计学意义(P<0.05)。重度组的PCT、H-FABP、CK-MB、CK、hs-cTnT均高于轻度组,差异具有统计学意义(P<0.05)。PCT、HFABP、CK-MB、CK、hs-cTnT水平升高是影响冠心病患者心肌损伤严重程度的危险因素,各项指标及五项联合预测心肌损伤严重程度的AUC值分别为(0.666、0.753、0.750、0.738、0.770、0.843,P<0.05)。结论PCT、H-FABP、CK-MB、CK、hs-cTnT在冠心病患者呈高表达趋势,且其水平会随心肌损伤程度而升高。Objective To investigate clinical appraised value of procalcitonin(PCT),myocardial fatty acid binding protein(HFABP),myocardial enzyme combined with myocardial hypersensitive troponin T(hs-cTnT)about myocardial injury in patients with coronary heart disease.Methods A total of 138 patients with coronary heart disease diagnosed and treated between January 2022 and April 2023 were selected retrospectively as the observation group,and 69 healthy examinees during the same period were selected as the control group.According to the degree of myocardial injury,they were divided into a mild group(undergoing single-vessel disease,n=92)and a severe group(undergoing double-vessel disease or three-vessel disease,n=46).PCT,H-FABP,creatine kinase isoenzyme(CK-MB),creatine kinase(CK)and hs-cTnT were analyzed and working curves were drawn to analyze the area under the curve(AUC)value by SPSS22.0 software.And then the sensitivity and specificity for predicting the degree of myocardial injury in patients with coronary heart disease were evaluated.Results PCT,H-FABP,CK-MB,CK and hs-cTnT in the observation group were higher than those in the control group,with statistically significant differences(P<0.05).Additionally,PCT,H-FABP,CK-MB,CK and hscTnT levels in the severe group were greater than those in the mild group,also showing statistically significant differences(P<0.05).Logistic regression analysis indicated that elevated levels of PCT,H-FABP,CK-MB,CK and hs-cTnT levels were risk factors for the severity of myocardial injury in patients with coronary heart disease.ROC curve analysis revealed that the AUC values for PCT,HFABP,CK-MB,CK,hs-cTnT and the combined prediction of myocardial injury severity were(0.666,0.753,0.750,0.738,0.770,0.843,P<0.05),respectively.Conclusion PCT,H-FABP,CK-MB,CK and hs-cTnT are significantly elevated in patients with coronary heart disease,and their levels increase with the severity of myocardial injury.

关 键 词：降钙素原 心肌型脂肪酸结合蛋白 心肌酶谱 心肌超敏肌钙蛋白T 冠心病 心肌损伤 

分 类 号：R541.4[医药卫生—心血管疾病]