水中β受体阻滞剂类心血管药物污染研究进展  

Review onβ-blocker Cardiovascular Drug Pollution in Water

作　　者：王倩 李青云[2] 何灿 王梦玉 李久义 张忠国[1,3,4] WANG Qian;LI Qingyun;HE Can;WANG Mengyu;LI Jiuyi;ZHANG Zhongguo(National Engineering Laboratory of Circular Economy,Institute of Resources and Environment,Beijing Academy of Science and Technology,Beijing 100089,China;China Academy of Space Technology,Beijing 100094,China;School of Environment,Beijing Jiaotong University,Beijing 100044,China;Key Laboratory of Energy-Water Conservation and Wastewater Resources Recovery of China National Light Industry,Beijing 100089,China)

机构地区：[1]北京市科学技术研究院资源环境研究所全国循环经济工程实验室,北京100089 [2]中国空间技术研究院,北京100094 [3]北京交通大学环境学院,北京100044 [4]中国轻工业节能节水与废水资源化重点实验室,北京100089

出　　处：《环境科学与技术》2025年第1期118-126,共9页Environmental Science & Technology

基　　金：国家重点研发计划项目(2022YFC3203001,2022YFC3203003);北京市科学技术研究院市级财政资金创新工程项目(24CA006);北京市科学技术研究院市级财政创新培育项目(24CB002-07,24CB002-03)。

摘　　要：随着心血管药物使用量的逐年上升,各种环境介质中已普遍检测到心血管药物的存在。由于其生物累积性与潜在毒性,如何有效控制水中心血管类药物污染物及评估其生态风险是目前研究的热点。文章以β受体阻滞剂为典型心血管药物,主要阐述其在环境中的分布、迁移、转化和生态毒性,目前已在各类环境样品中检测到多达12种β受体阻滞剂,相关研究多集中于废水和地表水,地下水中的研究较少。文章总结了其污染控制技术,提出重点研究方向:(1)加强不同环境基质中的监测、深入调查其在中国不同地区的环境分布状况;(2)深入研究β受体阻滞剂的代谢途径、代谢物及其生态效应,以及混合药物的协同生物学效应,以期为水中心血管药物的治理和风险控制提供参考。With the increasing use of cardiovascular drugs,a large number of cardiovascular drugs have been detected in various environmental compartments.Due to their bioaccumulation and potential toxicity,how to effectively control cardiovas-cular drug contaminants in water environment and assess their ecological risks are currently the focus of research.In this paper,β-blockers are taken as typical cardiovascular drugs,and their distribution,migration,transformation and ecotoxicity in the environment are mainly discussed.Up to 12 kinds ofβ-blockers have been detected in various environmental samples.Most studies focus on wastewater and surface water,and there are few studies on cardiovascular drugs in groundwater.The technology of cardiovascular drug pollution control was summarized,and the key research directions were put forward:(1)It is necessary to strengthen the monitoring of different environmental substrates and investigate their environmental distri-bution in different regions of China;(2)It is necessary to further study the metabolic pathways,metabolites and their ecologi-cal effects of beta blockers,as well as the synergistic biological effects of mixed drugs,in order to provide references for the management and risk control of cardiovascular drugs in water.

关 键 词：受体阻滞剂 阿替洛尔 生态毒性 心血管药物 

分 类 号：X52[环境科学与工程—环境工程]