肌肉干细胞对骨骼肌健康的多重调控  

The Multiple Roles of Muscle Stem Cells in Skeletal Muscle Health

作　　者：胡苹 HU Ping(Key Laboratory of Biological Targeting Diagnosis,Therapy and Rehabilitation of Guangdong Higher Education Institutes,the Fifth Afiliated Hospital of Guangzhou Medical University,Guangzhou 510005,China;Guangzhou Laboratory,Guangzhou 510005,China)

机构地区：[1]广州医科大学附属第五医院广东省生物靶向与诊治与康复工程技术研究中心,广州510005 [2]广州国家实验室,广州510005

出　　处：《中国细胞生物学学报》2025年第1期1-7,共7页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:32170804、82361148131);ZJ人才(批准号:2021JC0Y068)资助的课题。

摘　　要：肌肉干细胞是存在于成体骨骼肌中的一种组织干细胞,能够特异性分化为肌管细胞,从而实现对骨骼肌损伤的修复,是骨骼肌损伤修复再生的主要执行者。肌肉干细胞具有较高的异质性,其命运转化受到微环境因子和细胞内源转录与表观遗传网络的精密调控。随着更多准确模拟患者表型的动物模型的建立,在这些模型中的新研究结果表明肌肉干细胞病变是很多骨骼肌疾病发生和发展的重要原因,同时肌肉干细胞功能退变也是青少年特发性脊柱侧弯等传统意义上的非骨骼肌疾病的发生与发展的重要原因。因此,建立有功能的肌肉干细胞的体外长期扩增体系对于通过细胞治疗的方式治疗肌肉干细胞相关的骨骼肌和非骨骼肌疾病有重要意义。Muscle stem cells are a group of tissue stem cells present in skeletal muscles.Muscle stem cells can specifically differentiate to myotubes and support the regeneration of skeletal muscles.Muscle stem cells are the major executors of muscle regeneration.They are highly heterogeneous and regulated by a well knitted network of microenvironment and cell intrinsic molecular signaling.Not only many skeletal diseases but also nonmuscle diseases like adolescent idiopathic scoliosis turn out to be caused by the dysfunction of muscle stem cells.Therefore,muscle stem cell transplantation will improve and cure these stem cell related diseases.The establishment of the in vitro expansion system to expand functional muscle stem cells has great impacts on the development of cell therapies for these muscle stem cell related diseases.

关 键 词：肌肉干细胞 再生 骨骼肌疾病 

分 类 号：R685[医药卫生—骨科学]