钯催化羧基导向的C(sp^(2))—H键烷基化/环化合成2-(1-异色满酮-3-基)乙醛衍生物  

Palladium-Catalyzed Synthesis of 2-(1-Isochromen-3-yl)acetalde-hydes via Carboxyl-Directed C(sp^(2))—H Alkylation/Annulation

作　　者：王悦 杨旭艳 刘添雨 李团结 张凯 姚昌盛 Yue Wang;Xuyan Yang;Tianyu Liu;Tuanjie Li;Kai Zhang;Changsheng Yao(School of Chemistry and Materials Science,Jiangsu Normal University,Xuzhou,Jiangsu 221116)

机构地区：[1]江苏师范大学化学与材料科学学院,江苏徐州221116

出　　处：《有机化学》2024年第11期3556-3563,共8页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21772070)资助项目。

摘　　要：在醋酸钯催化下,以芳酸和碳酸乙烯亚乙酯为原料,通过羧基导向的C—H键烷基化/环化实现了2-(1-异色满酮-3-基)乙醛衍生物的合成.该方法具有原料简单易得,操作简便等优点,为该类异色满酮衍生物的合成提供了一种有效方法.A Pd(OAc)2-catalyzed efficient synthesis of 2-(1-isochromen-3-yl)acetaldehyde derivatives was achieved by the carboxyl-directed C—H bond alkylation/annulation of aryl acids with vinyl ethylene carbonate.This method has the advan-tages of ready availability of starting materials and operational simplicity,providing an alternative access to isochroman-1-one derivatives.

关 键 词：醋酸钯 芳酸 碳酸乙烯亚乙酯 异色满酮 

分 类 号：O621.251[理学—有机化学]