电子和质子辐照^(100)Mo制备^(99)Mo/^(99)mTc对比实验  

Comparative Experiment on the Preparation of ^(99)Mo/^(99)mTc via Electron and Proton Irradiation of 100Mo

作　　者：陈德胜 黄清钢 曹石巍 秦芝[1,2,3] CHEN Desheng;HUANG Qinggang;CAO Shiwei;QIN Zhi(Institute of Modern Physics,Chinese Academy of Sciences,Lanzhou 730000,China;Advanced Energy Science and Technology Guangdong Laboratory,Huizhou 516000,China;Gansu Isotope Laboratory,Lanzhou 730000,China)

机构地区：[1]中国科学院近代物理研究所,兰州730000 [2]先进能源科学与技术广东省实验室,惠州516000 [3]甘肃省同位素实验室,兰州730000

出　　处：《同位素》2025年第1期30-38,共9页Journal of Isotopes

基　　金：中国科学院“西部之光”项目(xbzglzb2022001)。

摘　　要：^(99)Mo/^(99)mTc是全球应用最广泛的医用显影核素,目前的供应依赖几座濒临退役的核反应堆。相比反应堆而言,加速器的建造、运行及维护成本更低,布局更灵活。因此,粒子加速器制备^(99)Mo/^(99)mTc已成为研究热点,其中利用电子加速器辐照^(100)Mo制备^(99)Mo和质子加速器辐照^(100)Mo制备^(99)mTc是最具可行性的两种方法。本研究结合实验数据和蒙特卡洛模拟结果,对比了两种基于加速器制备^(99)Mo/^(99)mTc的优势和劣势。质子辐照^(100)Mo直接产生^(99)mTc,^(99)mTc产额高,但伴生Tc的其他同位素,尤其是^(99)gTc。而电子辐照^(100)Mo,可以产生高纯的^(99)Mo,且化学分离过程简单,能够制备成^(99)Mo-^(99)mTc发生器使用,相对更具优势。^(99)mTc derived from ^(99)Mo,stands as the preeminent radiopharmaceutical employed extensively in medical diagnostics worldwide.Its current production mainly relies on some near-retirement nuclear reactors.Compared to reactors,particle accelerators have extremely low construction,operational,and maintenance costs,and their layouts are highly flexible.Given these circumstances,the production of ^(99)Mo/^(99)mTc by accelerator has become a research hotspot,with using electron-beam to irradiate ^(100)Mo to produce ^(99)Mo and proton-beam to irradiate ^(100)Mo to produce ^(99)mTc being the two most feasible methods.This article compares the advantages and disadvantages of two methods for preparing ^(99)Mo/^(99)mTc based on accelerators through experiments and Monte Carlo simulations.Direct production of ^(99)mTc by proton accelerators,the advantage is higher yield,but other Tc isotopes,especially ^(99)gTc,are produced alongside.In contrast,irradiating ^(100)Mo by electrons not only can produce high-purity ^(99)Mo with a simpler chemical separation process,but also make it suitable for preparing ^(99)Mo-^(99)mTc generators,which is relatively more advantageous.

关 键 词：质子 电子 加速器 蒙特卡罗模拟 ^(99)Mo/^(99)mTc 

分 类 号：TL921[核科学技术—核燃料循环与材料]