原发性免疫缺陷病患儿感染现状及影响因素分析  

Infection status and influencing factors in children with primary immunodeficiency disease

作　　者：陶静 莫霖[2] Tao Jing;Mo Lin(Department of Rheumatology and Immunology,Children’s Hospital of Chongqing Medical University,National Clinical Research Center for Child Health and Disorders,Ministry of Education Key Laboratory of Child Development and Disorders,Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity;Outpatient Department of Children’s Hospital of Chongqing Medical University)

机构地区：[1]重庆医科大学附属儿童医院风湿免疫科,儿童发育疾病研究教育部重点实验室,国家儿童健康与疾病临床医学研究中心,儿童感染与免疫罕见病重庆市重点实验室,重庆400014 [2]重庆医科大学附属儿童医院门诊部,重庆400014

出　　处：《重庆医科大学学报》2024年第12期1613-1618,共6页Journal of Chongqing Medical University

基　　金：重庆市自然科学基金面上资助项目(编号:CSTB2024NSCQ-MSX1093);重庆医科大学附属儿童医院护理培育课题资助项目(编号:CHCQMU2021.09)。

摘　　要：目的:探究原发性免疫缺陷病(primary immunodeficiency disease,PID)患儿感染现状及影响因素,为降低原发性免疫缺陷病患儿感染风险提供依据。方法:采用便利抽样法,以入住重庆市某三级甲等儿童专科医院的146例原发性免疫缺陷病患儿为调查对象,采用二元logistics回归分析原发性免疫缺陷病患儿感染的影响因素。结果:住院天数(OR=1.010,95%CI=1.005~1.014)、是否使用抗生素(OR=1.402,95%CI=1.247~1.575)、是否使用免疫抑制剂(OR=1.231,95%CI=1.109~1.366)、是否使用丙种球蛋白(OR=0.831,95%CI=0.751~0.92)、住院费用10000~<20000元(OR=1.229,95%CI=1.078~1.402;≥20000元OR=0.83,95%CI=0.704~0.979)、免疫球蛋白G(immunoglobulin G,IgG)定性结果(OR=1.095,95%CI=1.008~1.183)、C反应蛋白(Creactive protein,CRP)(OR=1.406,95%CI=1.261~1.568)、中性粒细胞计数(OR=0.708,95%CI=0.613~0.818)和照护者文化水平高中(OR=0.796,95%CI=0.685~0.925;大专及以上OR=0.809,95%CI=0.729~0.899)是住院过程感染的影响因素。结论:原发性免疫缺陷病(PID)患儿的影响因素众多,评估其感染风险至关重要。早期识别其感染风险,针对性分级管理预防感染,对改善PID患儿生活质量及延长寿命意义重大。Objective:To explore the infection status and influencing factors in children with primary immunodeficiency disease(PID),and to provide evidence for reducing the risk of infection in children with PID.Methods:A total of 146 children with PID admitted to a grade A tertiary children’s hospital in Chongqing were investigated by the convenience sampling method,and the influencing factors for infection in children with PID were analyzed by binary logistics regression.Results:The length of hospital stay(odds ratio[OR]=1.010,95%CI=1.005-1.014),use of antibiotics(OR=1.402,95%CI=1.247-1.575),use of immunosuppressants(OR=1.231,95%CI=1.109-1.366),use of gamma globulin(OR=0.831,95%CI=0.751-0.92),hospital costs(10,000-20,000 yuan:OR=1.229,95%CI=1.078-1.402;20,000 yuan and above:OR=0.83,95%CI=0.704-0.979),immunoglobulin G qualitative result(OR=1.095,95%CI=1.008-1.183),C-reactive protein(OR=1.406,95%CI=1.261-1.568),neutrophil count(OR=0.708,95%CI=0.613-0.818),and education level of caregivers(high school:OR=0.796,95%CI=0.685-0.925;junior college or above:OR=0.809,95%CI=0.729-0.899)were influencing factors for infection during hospitalization.Conclusion:There are many influencing factors in children with PID,and it is crucial to assess their risk of infection.Early identification of the risk of infection and targeted grading management for infection prevention are of great significance for improving the quality of life and prolonging the lifespan of children with PID.

关 键 词：原发性免疫缺陷病 感染 现状调查 护理 

分 类 号：R114[医药卫生—卫生毒理学]