探究C反应蛋白联合血脂检测在冠心病诊断中的重要性及应用价值  

Explore the Importance and Application Value of C-reactive Protein Combined with Blood Lipid Detection in the Diagnosis of Coronary Heart Disease

作　　者：陈舒媛 张祥瑞 班孟琦 CHEN Shuyuan;ZHANG Xiangrui;BAN Mengqi(Department of Laboratory,Wuhai Mongolian Hospital of Traditional Chinese Medicine,Wuhai 016000,Inner Mongolia Autonomous Region,China)

机构地区：[1]乌海市中医蒙医医院检验科,内蒙古乌海016000

出　　处：《系统医学》2024年第23期31-34,共4页Systems Medicine

摘　　要：目的 探究C反应蛋白(C-reactive protein, CRP)联合血脂检测在冠状动脉粥样硬化性心脏病(冠心病诊断中的重要性及应用价值。方法 回顾性选取2023年1月-2024年4月在乌海市中医蒙医医院就诊的80例冠心病患者的临床资料作为疾病组,并选取同期80名健康体检者的临床资料作为健康组。对比两组CRP、血脂水平,以及上述指标单一及联合检测的诊断效能。结果 疾病组的CRP、甘油三酯、血清胆固醇、低密度脂蛋白胆固醇水平均高于健康组,高密度脂蛋白胆固醇水平低于健康组,差异有统计学意义(P均<0.05)。联合检测的灵敏度为97.50%(78/80)、特异度为98.75%(79/80)、准确度为98.13%(157/160)、阳性预测值为98.73%(78/79)、阴性预测值为97.53%(79/81),高于CRP检测的78.75%(63/80)、80.00%(64/80)、79.38%(127/160)、79.75%(63/79)、79.01%(64/81),以及血脂检测的85.00%(68/80)、86.25%(69/80)、85.63%(137/160)、86.08%(68/79)、85.19%(69/81),三种检测方式的诊断效能比较,差异有统计学意义(χ^(2)=17.520、13.492、27.503、13.238、8.681,P均<0.05)。结论 CRP联合血脂检测在冠心病的诊断中具有重要的应用价值,其诊断效能优于单一指标的检测。Objective To explore the importance and application value of C-reactive protein(CRP)combined with blood lipid detection in the diagnosis of coronary atherosclerotic heart disease(coronary heart disease).Methods The clinical data of eighty patients with coronary heart disease who were treated in Wuhai Mongolian Hospital of Traditional Chinese Medicine from January 2023 to April 2024 were retrospectively selected as the disease group,and the clinical data of eighty healthy subjects in the same period were selected as the healthy group.The levels of CRP and blood lipid,as well as the diagnostic efficacy of single and combined detection of the above indicators were compared between the two groups.Results The levels of CRP,triglyceride,serum cholesterol and low density lipoprotein cholesterol in the disease group were higher than those in the healthy group,and the level of high density lipoprotein cholesterol were lower than that in the healthy group,the differences were statistically significant(all P<0.05).In addition,the sensitivity,specificity,accuracy,positive predictive value and negative predictive value of combined detection were 97.50%(78/80),98.75%(79/80),98.13%(157/160),98.73%(78/79)and 97.53%(79/81),higher than 78.75%(63/80),80.00%(64/80),79.38%(127/160),79.75%(63/79),79.01%(64/81)in CRP detection,higher than blood lipid detection's 85.00%(68/80),86.25%(69/80),85.63%(137/160),86.08%(68/79)and 85.19%(69/81),compared with diagnostic efficiency of the three detection methods,the differences were statistically significant(χ^(2)=17.520,13.492,27.503,13.238,8.681,all P<0.05).Conclusion CRP combined with blood lipid detection has important application value in the diagnosis of coronary heart disease,and its diagnostic efficiency is better than that of single index detection.

关 键 词：C反应蛋白 血脂检测 冠心病诊断 

分 类 号：R446[医药卫生—诊断学]