红细胞及网织红细胞参数在巨幼细胞贫血中的临床诊断价值  

The Clinical Diagnostic Value of Red Blood Cell and Reticulocyte Parameters in Megaloblastic Anemia

作　　者：王春霞 WANG Chunxia(Department of Clinical Laboratory,Liangshan People's Hospital,Jining 272600,Shandong,China)

机构地区：[1]梁山县人民医院检验科,山东济宁272600

出　　处：《系统医学》2024年第23期68-71,共4页Systems Medicine

摘　　要：目的 探究网织红细胞(reticulocyte, Ret)、平均红细胞体积(mean corpuscular volume, MCV)、平均红细胞血红蛋白量(mean corpuscular hemoglobin, MCH)、红细胞分布宽度(red cell distribution width, RDW)在巨幼细胞贫血诊断中的临床诊断价值。方法 回顾性选取2021年1月-2023年12月梁山县人民医院收治的75例巨幼细胞贫血患儿资料作为贫血组,收集同期75名健康儿童资料作为健康组。比较两组的Ret、MCV、MCH、RDW水平差异,分析上述指标单独及联合诊断巨幼细胞贫血的效能。结果 贫血组Ret、MCV、MCH、RDW均高于健康组,差异有统计学意义(P均<0.05)。四项指标联合检测的敏感度为97.33%(73/75)、特异度为98.67%(74/75)、准确度为98.00%(147/150)、阳性预测值为98.65%(73/74)、阴性预测值为97.37%(74/76),误诊率为1.33%(1/75)、漏诊率为2.67%(2/75),均优于单一检测。结论 红细胞及网织红细胞参数在巨幼细胞贫血的诊断中具有重要临床价值,Ret、MCV、MCH、RDW联合检测可以提高巨幼细胞贫血的诊断效能。Objective To explore the clinical diagnostic value of reticulocyte(Ret),mean corpuscular volume(MCV),mean corpuscular hemoglobin(MCH),and red cell distribution width(RDW)in the diagnosis of megaloblastic anemia.Methods Data of seventy-five children with megaloblastic anemia treated in Liangshan County People's Hospital from January 2021 to December 2023 were retrospectively selected as the anemia group,and data of seventy-five healthy children were collected as the healthy group during the same period.The differences in Ret,MCV,MCH and RDW levels between the two groups were compared,and the efficacy of the above indexes alone and in combination in the diagnosis of megaloblastic anemia was analyzed.Results Ret,MCV,MCH and RDW in anemia group were higher than those in healthy group,and the differences were statistically significant(all P<0.05).The sensitivity of combined the four indexes was 97.33%(73/75),specificity was 98.67%(74/75),accuracy was 98.00%(147/150),positive predictive value was 98.65%(73/74),negative predictive value was 97.37%(74/76),the misdiagnosis rate was 1.33%(1/75)and missed diagnosis rate was 2.67%(2/75),the diagnostic efficiency of combined detection was better than those of single detection of each index.Conclusion Erythrocyte and reticulocyte parameters have important clinical value in the diagnosis of megaloblastic anemia,Ret,MCV,MCH,RDW combined detection can improve the diagnostic efficiency of megaloblastic anemia.

关 键 词：巨幼细胞贫血 红细胞参数 网织红细胞 诊断效能 临床价值 

分 类 号：R446[医药卫生—诊断学]