分析替罗非班在老年ST段抬高型心肌梗死患者经皮冠脉介入治疗中的应用效果  

To Analyze the Application Effect of Tirofiban in Percutaneous Coronary Intervention in Elderly Patients with ST-segment Elevation Myocardial Infarction

作　　者：奚克钰 许旭茂 欧阳耀汉 吴耿先 XI Keyu;XU Xumao;OUYANG Yaohan;WU Gengxian(Department of Internal Medicine,Section Five,Guangdong Second People's Hospital Huilai Hospital,Jieyang 515200,Guangdong,China)

机构地区：[1]广东省第二人民医院惠来医院内五科,广东揭阳515200

出　　处：《系统医学》2024年第23期110-113,共4页Systems Medicine

摘　　要：目的 观察替罗非班在老年ST段抬高型心肌梗死(ST-segment elevation myocardial infarction,STEMI)患者经皮冠脉介入(percutaneous coronary intervention,PCI)治疗中的应用效果。方法 非随机选取广东省第二人民医院惠来医院于2022年1月-2023年12月经PCI治疗的70例老年STEMI患者为研究对象。根据治疗方式的不同分为两组,各35例。对照组在PCI围术期接受常规双联抗血小板治疗,研究组在PCI术中联合替罗非班治疗。比较两组患者治疗效果、不良心血管事件、心肌灌注指标。结果 研究组治疗后的血流正常比例较对照组高,差异有统计学意义(P<0.05)。研究组90 d内不良心血管事件发生率为5.17%(2/35),低于对照组的28.57%(10/35),差异有统计学意义(χ^(2)=4.928,P<0.05)。研究组治疗后心肌灌注指标优于对照组,差异有统计学意义(P均<0.05)。结论 替罗非班在STEMI患者PCI治疗中的应用对改善患者心肌灌注、减少不良心血管事件发生均有显著效果,对帮助患者血运恢复正常有明显作用。Objective To observe the application effect of tirofiban in elderly patients with ST-segment elevation myocardial infarction(STEMI)in percutaneous coronary intervention(PCI).Methods A total of seventy elderly STEMI patients who underwent PCI in Huilai Hospital of Guangdong Second People's Hospital from January 2022 to December 2023 were non-randomly selected as the study subjects.According to the different treatment methods,they were divided into two groups,thirty-five cases in each group.The control group received conventional dual antiplatelet therapy during the perioperative period of PCI,and the study group was treated with tirofiban during PCI.The thera⁃peutic effect,adverse cardiovascular events and myocardial perfusion indexes were compared between the two groups.Results The proportion of normal blood flow after treatment in the study group was higher than that in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse cardiovascular events within 90 days in the study group was 5.17%(2/35),which was lower than 28.57%(10/35)in the control group,and the difference was statistically significant(χ^(2)=4.928,P<0.05).The myocardial perfusion index of the study group was better than that of the control group after treatment,and the differences were statistically significant(both P<0.05).Conclusion The application of tirofiban in PCI treatment of STEMI patients has a significant effect on improving myocardial perfusion and reducing adverse cardiovascular events,and has an excellent effect on helping patients return to normal blood supply.

关 键 词：经皮冠脉介入 ST段抬高型心肌梗死 老年患者 替罗非班 应用效果 

分 类 号：R541[医药卫生—心血管疾病]