不同认知负荷下年轻人言语过程中大脑皮质激活区域和功能连接性的差异分析  

Analysis of Differences in Cortical Activation Areas and Functional Connectivity During Speech in Young People Under Different Cognitive Loads

作　　者：江紫辉 陈秀恩[1,2,3] 郑洁皎 郑拥军[1] 张云云[3] 刘向云[2] 仇丽雯 张晨晨 宁志超 JIANG Zihui;CHEN Xiuen;ZHENG Jiejiao;ZHENG Yongjun;ZHANG Yunyun;LIU Xiangyun;QIU Liwen;ZHANG Chenchen;NING Zhichao(Huadong Hospital,Fudan University,Shanghai 200040,China;Shanghai University of Sport;不详)

机构地区：[1]复旦大学附属华东医院,上海200040 [2]上海体育大学 [3]上海中医药大学附属岳阳中西医结合医院 [4]上海第四康复医院

出　　处：《听力学及言语疾病杂志》2025年第1期40-45,共6页Journal of Audiology and Speech Pathology

基　　金：上海市卫健委面上项目(202240256);上海康复医学临床医学研究中心项目(21MC1930200);华东医院横向课题;华东医院重点学科建设(LCZX2206)。

摘　　要：目的 研究不同认知负荷下言语时年轻人大脑皮质激活和功能连接性的差异。方法 21例受试者(平均年龄21.9±1.33岁)分别在一致条件(颜色词语与其字体颜色相对应)和不一致条件(颜色词语与其字体颜色不相对应)下朗读嵌入了颜色词语的短句,颜色词语要求读字体的颜色而不是词语本身的读音。采用功能性近红外光谱成像技术(functional near-infrared spectroscopy, fNIRS)分析大脑左右的背外侧前额叶皮质(dorsolateral prefrontal cortex, DLPFC)以及左右的辅助运动区皮质(supplementary motor area, SMA)的皮质激活程度[含氧血红蛋白(HbO)浓度变化]和功能连接(脑区间HbO的值的Pearson相关性)差异。结果 fNIRS结果显示,与一致条件下相比较,在不一致条件下,R-DLPFC(t=3.4,P=0.003)、L-DLPFC(t=2.58,P=0.019)、R-SMA(t=3.59,P=0.002)和L-SMA(t=4.06,P=0.001)HbO浓度变化均显著升高,且R-DLPFC与L-DLPFC间的相关性显著增强(t=2.44,P=0.025),但左、右SMA之间以及SMA与DLPFC之间的相关性差异无统计学意义(P>0.05)。结论 在不一致条件下进行言语时,由于认知负荷增加,DLPFC和SMA的皮质激活程度增加,且左、右DLPFC之间的功能连接强度增加。Objective To investigate the differences in cortical activation and functional connectivity during speech under different cognitive loads in young individuals.Methods Twenty-one participants(mean age 21.9±1.33 years)were instructed to read short sentences embedded with color words under both congruent(where the color words matched the font color)and incongruent(where the color words did not match the font color)conditions.The color words required reading the font color instead of the word itself.Functional near-infrared spectroscopy(fNIRS)was utilized to analyze differences in cortical activation(changes in HbO concentration)and functional connectivity(Pearson correlation of HbO between brain regions)in the dorsolateral prefrontal cortex(DLPFC)and supplementary motor area(SMA)bilaterally.Results The fNIRS results revealed significant increase in HbO concentration changes in the RDLPFC(t=3.4,P=0.003),LDLPFC(t=2.58,P=0.019),RSMA(t=3.59,P=0.002),and LSMA(t=4.06,P=0.001)under the incongruent condition compared to the congruent condition.Additionally,there was a significant enhancement in the correlation between RDLPFC and LDLPFC(t=2.44,P=0.025).However,the differences in correlation between left and right SMA,as well as between SMA and DLPFC,were not statistically significant(P>0.05).Conclusion These findings suggest that during speech under incongruent conditions,increased cognitive load leads to elevated cortical activation in the DLPFC and SMA,along with increased functional connectivity between the left and right DLPFC.

关 键 词：认知负荷 功能性近红外光谱成像技术 皮质激活 功能连接 

分 类 号：R338[医药卫生—人体生理学]