宫内慢性缺氧子代鼠的听力损失结果分析  

Analysis of Hearing Loss in Offspring Mice with Chronic Intrauterine Hypoxia

作　　者：魏日富 陈丽文 刘平 朱忠寿 郭丽芳 曾笑梅 WEI Rifu;CHEN Liwen;LIU Ping;ZHU Zhongshou;GUO Lifang;ZENG Xiaomei(School of Clinical Medicine,Fujian Medicine University,Fuzhou 350108,China;Department of Otolaryngology Head and Neck Surgery,Ningde Affiliated Hospital of Ningde Normal University;不详)

机构地区：[1]福建医科大学临床医学部,福州350108 [2]宁德师范学院附属宁德市医院耳鼻咽喉科 [3]宁德师范学院附属宁德市医院妇产科

出　　处：《听力学及言语疾病杂志》2025年第1期62-65,共4页Journal of Audiology and Speech Pathology

基　　金：福建省自然科学基金面上项目(2020J011343)。

摘　　要：目的 探讨宫内慢性缺氧对子代鼠听力的影响及可能的致聋机制。方法 选用10只SD孕鼠建立宫内慢性缺氧模型作为缺氧组,另选10只不做缺氧处理作为对照组,对孕鼠进行动脉血气分析,对子代鼠进行ABR测试,比较各组结果。结果 缺氧组孕鼠PaO2和SaO2显著低于对照组;缺氧组子代鼠21 d和56 d的听力损失率及波Ⅲ反应阈均显著高于同期对照组,随着时间推移,逐渐改善;但其波Ⅱ、Ⅲ潜伏期及Ⅰ-Ⅱ、Ⅱ-Ⅲ和I-Ⅲ波间期仍显著高于对照组,波Ⅲ振幅和Ⅲ/Ⅰ振幅比显著低于对照组;21 d波Ⅲ反应阈异常而56 d恢复正常的缺氧组子代鼠,其波Ⅱ、Ⅲ潜伏期及Ⅰ-Ⅱ、Ⅱ-Ⅲ和I-Ⅲ波间期均显著高于、波Ⅲ振幅和Ⅲ/Ⅰ振幅比显著低于21 d和56 d波Ⅲ反应阈均正常的对照组及缺氧组。缺氧组子代鼠听力损失以双侧为主。结论 宫内慢性缺氧可导致子代不同程度的听力损失,子代出生后机体可进行一定程度的发育代偿和修复。Objective To study the effects and the possible mechanism of the hearing loss of offspring mice with chronic intrauterine hypoxia.Methods Ten healthy SD pregnant mice with SPF level were selected to establish an intrauterine hypoxia model as the hypoxia group,while another ten healthy SD pregnant mice without hypoxia treatment were selected as the control group.Arterial blood gas analysis was performed on pregnant mice and auditory brainstem response(ABR)testing was performed on their offspring after birth,and the results of each group were compared.Results The PaO 2 and SaO 2 of the hypoxic group were significantly lower than those of in the control group.The hearing loss rate and wave III response threshold of the offspring mice of the hypoxia group were significantly higher than those of in the control group at 21 and 56 days,but over time,the hearing loss rate and wave III response threshold of the hypoxia group improved compared to before.Although some offspring mice in the hypoxic group at 21 day and 56 day had normal III wave response thresholds,their wave II and III latency,as well as the latency between I-II,II-III,and I-III,were still significantly higher,while the amplitude of wave III and the ratio of III/I were significantly lower than those of in the control group during the same period.For hypoxic offspring mice with abnormal wave III response threshold at 21 days and normal wave III response threshold at 56 days,the latency of waves II and III,as well as the latency between I-II,II-III,and I-III were significantly higher,while the amplitude of wave III and the ratio of III/I were significantly lower than those of in the control group and hypoxic group with normal wave III response thresholds at 21 days and 56 days.The hearing loss of offspring mice in the hypoxia group was mainly bilateral.Conclusion Chronic intrauterine hypoxia can lead to varying degrees of hearing loss,but this type of hearing loss has a certain degree of retrogression in the early stages,and the body can undergo limited develo

关 键 词：宫内慢性缺氧 听性脑干反应 听力损失 

分 类 号：R764[医药卫生—耳鼻咽喉科]