主观性耳鸣的中枢发病机制研究进展  

Research Progress on Central Pathogenesis of Subjective Tinnitus

作　　者：黄辛钊 武敬沂 彭华 HUANG Xinzhao;WU Jingyi;PENG Hua(The First School of Clinical Medicine,Southern Medical University,Guangzhou 510515,China;不详)

机构地区：[1]南方医科大学第一临床医学院,广州510515 [2]南部战区总医院耳鼻咽喉头颈外科

出　　处：《听力学及言语疾病杂志》2025年第1期87-91,共5页Journal of Audiology and Speech Pathology

基　　金：广州市科技计划项目(201904010081);军队医学科技青年培育计划(20QNPY085);广东省重大科技专项资金项目(2013A022100035)。

摘　　要：耳鸣指在无外界声源时,耳内或颅内感知有一种或多种声音,仅患者能感觉到的耳鸣称为主观性耳鸣,其产生的中枢机制与听觉及非听觉中枢系统均有关系。中枢听觉传导通路中的中枢增益、神经元自发放电率增加、神经元之间同步性增加是耳鸣产生的主要因素。此外,非听觉中枢系统的体感通路以及边缘系统同样对耳鸣有着巨大的影响。主观性耳鸣的发病机制的研究可为其诊断及治疗提供进一步研究思路。Tinnitus refers to the perception of one or more sounds in the ear or skull without an external sound source,and subjective tinnitus is only perceived by the patient.The central mechanism of subjective tinnitus is related to both the auditory and non-auditory central nervous system.The main factors of tinnitus production in the central auditory conduction pathway are central gain,increased spontaneous firing rate of neurons,and increased synchronization between neurons.In addition,the somatosensory pathway and the limbic system in the non-auditory central nervous system also have a huge impact on tinnitus.The study of the pathogenesis of subjective tinnitus can provide further research ideas for its diagnosis and treatment.

关 键 词：主观性耳鸣 中枢机制 研究进展 

分 类 号：R764.45[医药卫生—耳鼻咽喉科]