纳米酶在眼部疾病治疗中的研究进展  

Research Progress on Nanozymes in the Treatment of Ophthalmic Diseases

作　　者：刘爽[1] 滕思莹[1] 惠鹏 孙雅彬[1] LIU Shuang;TENG Si-Ying;HUI Peng;SUN Ya-Bin(Ophthalmology Department,First Hospital of Jilin University,Changchun 130021,China)

机构地区：[1]吉林大学第一医院眼科,长春130021

出　　处：《应用化学》2024年第12期1679-1696,共18页Chinese Journal of Applied Chemistry

基　　金：吉林省科技发展项目(No.20200201424JC)资助。

摘　　要：适量活性氧(ROS)在调节生物体的多种生理功能中扮演着关键角色。ROS含量的增加可能会导致氧化应激和生物分子损伤,从而导致各种疾病。由于长期暴露在光线下,具有高代谢活性的眼睛尤其容易受到氧化应激影响,与多种眼部疾病的发生和发展息息相关。因此,清除ROS维持氧化还原稳态至关重要。随着纳米技术的进步,具有类酶活性的纳米酶,如过氧化氢酶(CAT)、超氧化物歧化酶(SOD)等,因具有稳定性好、易于制备和生物相容性好等优点,在调节氧化还原稳态、缓解ROS相关损伤等领域受到了广泛关注。在本综述中,系统地总结了ROS与眼部疾病的关系、纳米酶在眼部疾病治疗中的研究进展,以及未来临床转化中存在的挑战和难题。Moderate levels of reactive oxygen species(ROS)are essential in modulating a range of physiological processes in living organisms.An increase in ROS content can result in oxidative stress and harm to biological molecules,resulting in various diseases.Due to prolonged exposure to light,the eyes with high metabolic activity are especially vulnerable to oxidative stress,which is strongly associated with the onset and progression of various ophthalmic diseases.Therefore,it is crucial to eliminate ROS and maintain oxidation-reduction homeosta.With the progress of nanotechnology,nanozymes with enzyme-like activities,such as catalase(CAT)and superoxide dismutase(SOD),have attracted extensive attention due to their stability,ease of preparation,and good biocompatibility,in regulating oxidation-reduction homeosta and alleviating ROS-related damage.In this review,we systematically summarize the relationship between reactive oxygen species and ophthalmic diseases,the research progress of nanozymes in the treatment of ophthalmic diseases,and the challenges and difficulties in clinical translation.

关 键 词：纳米酶 眼部疾病 活性氧 

分 类 号：O611[理学—无机化学]