恙虫病呼吸系统并发症及诊断技术进展  

Respiratory complications and progress in diagnostic techniques of scrub typhus

作　　者：倪磊[1] 金亦婷 孙晔 殷堃 李庆云[1] Ni Lei;Jin Yiting;Sun Ye;Yin Kun;Li Qingyun(Department of Respiratory and Critical Care Medicine,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China;Department of Respiratory and Critical Care Medicine,People′s Hospital of Mojiang Hani Autonomous County,Pu′er 654899,China;Department of Respiratory and Critical Care Medicine,Wuxi Branch of Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Wuxi 214000,China;Shanghai Jiao Tong University School of Medicine-National Research Center for Tropical Diseases Global Health Institute,Shanghai 200025,China)

机构地区：[1]上海交通大学医学院附属瑞金医院呼吸与危重症医学科,上海200025 [2]墨江哈尼族自治县人民医院呼吸与危重症医学科,普洱654899 [3]上海交通大学医学院附属瑞金医院无锡分院呼吸与危重症医学科,无锡214000 [4]上海交通大学医学院-国家热带病研究中心全球健康学院,上海200025

出　　处：《国际呼吸杂志》2024年第12期1371-1376,共6页International Journal of Respiration

基　　金：无锡市太湖人才计划-高端医学人才项目(RJWX-001);门楣之光-黄浦领军人才计划项目(RC20240019);云南省普洱市科技项目(ZCXM20240129)

摘　　要：恙虫病是一种虫媒性传染病,其病原体为恙虫病立克次体,主要流行于亚太地区,近年来发病率有升高趋势。恙虫病的基本病理是全身中小血管炎,临床表现多样化,重症患者病死率较高。恙虫病累及呼吸系统可出现多种并发症,临床表现从轻症到重症具有异质性,早期容易被误诊,延误诊断和治疗会导致重症发病率显著增高。本文对恙虫病的各种传统和新型实验室诊断技术作了总结和优缺点比较,目前临床诊治恙虫病多为经验性,亟待开发一种早期、快速、精准、成本可控的病原学诊断技术。Scrub typhus is an arthropod-borne infectious disease caused by the pathogen Orientia tsutsugamushi,predominantly prevalent in the Asia-Pacific region.In recent years,there has been an observed increase in its incidence.The fundamental pathology of scrub typhus involves systemic vasculitis affecting small and medium-sized blood vessels,with diverse clinical manifestations and can be life-threatening in severe cases.There are multiple complications when the respiratory system is affected by scrub typhus,showing a heterogeneity from mild to severe cases.It is prone to misdiagnosis in its early stages.Delays in diagnosis and treatment can significantly increase the incidence of severe cases.This article provided a comprehensive summary and comparison of the advantages and disadvantages of various traditional and novel laboratory diagnostic techniques for scrub typhus.Currently,clinical diagnosis and treatment of scrub typhus are largely empirical,highlighting an urgent need for the development of an early,rapid,accurate,and cost-effective etiological diagnostic technology.

关 键 词：丛林斑疹伤寒 恙虫病立克次体 宏基因组高通量测序 

分 类 号：R51[医药卫生—内科学]