广西地区196例男男性行为HIV感染者回顾性分析  

Retrospective analysis of 196 HIV-infected men who have sex with men in Guangxi region

作　　者：陆家荣 李铮 彭智鹏[3] 唐秀生[4] 黄思宇 郭婷[1] 韦高[1] 林有坤[1] 彭俊文 郑文军[1] LU Jiarong;LI Zheng;PENG Zhipeng;TANG Xiusheng;HUANG Siyu;GUO Ting;WEI Gao;LIN Youkun;PENG Junwen;ZHENG Wenjun(Department of Dermatology and Venereology,The First Affiliated Hospital of Guangxi Medical University,Nanning 530021,Guangxi,China;Department of Leprosy and Venereal Disease Prevention and Control,Dermatology Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,Guangxi,China;Department of Dermatology and Venereology,The Fourth People’s Hospital of Nanning,Nanning 530021,Guangxi,China;Department of Dermatology and Venereology,The Affiliated Hospital of Youjiang Medical University for Nationalities,Baise 533000,Guangxi,China)

机构地区：[1]广西医科大学第一附属医院皮肤性病科,广西南宁530021 [2]广西皮肤病医院麻风性病防治科,广西南宁530021 [3]广西南宁市第四人民医院皮肤性病科,广西南宁530021 [4]右江民族医学院附属医院皮肤性病科,广西百色533000

出　　处：《右江民族医学院学报》2024年第6期901-904,922,共5页Journal of Youjiang Medical University for Nationalities

基　　金：广西医疗卫生适宜技术开发与推广应用项目(S201671)。

摘　　要：目的分析男男性行为HIV感染者临床流行病学特征及合并皮肤病、晚期肛门疾病(肛门高级别鳞状上皮内病变和/或肛门癌)状况。方法从2003年1月至2023年12月广西医科大学第一附属医院、广西皮肤病医院、广西南宁市第四人民医院、右江民族医学院附属医院皮肤科住院的196例男男性行为HIV感染者中收集流行病学、合并皮肤病、晚期肛门疾病资料,分析相关的流行病学,皮肤病及晚期肛门疾病特征。结果男男性行为HIV感染者年龄为(36.44±17.17)岁,多处于未婚(54.08%),文化程度多为高中(42.86%),职业以工人为主(31.63%)。合并皮肤病的检出率为78.06%,合并单一皮肤病为42.35%,合并两种及以上皮肤病的检出率为35.71%,其中合并感染性皮肤病的检出率最高,为71.94%。男男性行为HIV感染者感染以金黄色葡萄球菌(42.35%)、念珠菌(56.12%)等为主。并且随着男男性行为HIV感染者CD4^(+)T淋巴细胞计数水平减低,皮肤病的检出率及并发皮肤病种类增加。男男性行为HIV感染者晚期肛门疾病的检出率为21.94%,其与CD4^(+)T淋巴细胞计数关联有统计学意义。结论男男性行为HIV感染者以具备一定知识水平的未婚工人为主,需要对这一人群进行针对性地干预,以降低艾滋病感染率。男男性行为HIV感染者以合并皮肤病的种类繁多且检出率高,并发皮肤病的种类及其预后与患者自身免疫力密切相关。自身免疫力越低、并发皮肤病的种类越多,越容易并发晚期肛门疾病,预后越差。Objective To analyze the clinical epidemiological characteristics of men who have sex with men(MSM)with HIV infection,as well as the status of concurrent skin diseases and advanced anal diseases(high-grade squamous intraepithelial lesions of the anus and/or anal cancer).Methods Epidemiological data,data on concurrent skin diseases,and data on advanced anal diseases were collected from 196 HIV-infected MSM hospitalized in the department of dermatology of the First Affiliated Hospital of Guangxi Medical University,Dermatology Hospital of Guangxi Zhuang Autonomous Region,the Fourth People’s Hospital of Nanning,and the Affiliated Hospital of Youjiang Medical University for Nationalities between January 2003 and December 2023,and relevant epidemiology,skin diseases,and advanced anal disease characteristics were analyzed.Results The mean age of the HIV-infected MSM was 36.44±17.17 years old,most of them were unmarried(54.08%),with a high-school education level(42.86%),and the majority of their occupations were workers(31.63%).The detection rate of concurrent skin diseases was 78.06%,with 42.35%having a single skin disease and 35.71%having two or more skin diseases.The highest detection rate of concurrent skin diseases was infectious skin diseases(71.94%).Staphylococcus aureus(42.35%)and Candida(56.12%)were the main infections among MSM.As the CD4^(+)T lymphocyte count decreased among HIV-infected MSM,the detection rate of skin diseases and the variety of concurrent skin diseases increased.The detection rate of advanced anal diseases among HIV-infected MSM was 21.94%,and there was a statistically significant association with the CD4^(+)T-lymphocyte count.Conclusion HIV-infected MSM are predominantly unmarried workers with a certain level of education,and targeted interventions are needed to reduce HIV infection rates among this population.HIV-infected MSM have a high detection rate and variety of concurrent skin diseases,and the types and prognosis of concurrent skin diseases are closely related to patients’own imm

关 键 词：男男性行为 HIV感染者 临床流行病学 皮肤病 晚期肛门疾病 

分 类 号：R512.91[医药卫生—内科学]