机械应力微创伤在银屑病关节炎发病机制中的研究进展  

Update of mechanical stress and microtrauma in the mechanisms of psoriatic arthritis

作　　者：顾晓澜 晏少琛 毕新岭 GU Xiaolan;YAN Shaochen;BI Xinling(Department of Dermatology,Shanghai Pudong Hospital,Fudan University Affiliated Pudong Medical Center,Shanghai 201399,China;Department of Dermatology,the First Affiliated Hospital of Naval Medical University,Shanghai 200433,China)

机构地区：[1]上海市浦东医院暨复旦大学附属浦东医院皮肤科,上海201399 [2]海军军医大学第一附属医院皮肤科,上海200433

出　　处：《中国麻风皮肤病杂志》2025年第2期140-144,共5页China Journal of Leprosy and Skin Diseases

基　　金：国家重点研发计划资助“海洋环境安全保障与岛礁可持续发展”重点专项(编号:2022-2.4);海军军医大学基础医学研究项目(编号:2022MS015);上海申康临床研究项目(编号:SHDC22022302)。

摘　　要：银屑病关节炎(psoriatic arthritis,PsA)严重可出现关节畸形,影响患者日常生活。近年来,国内外对银屑病关节炎发病机制的研究取得了较大进展,特别是关节局部微创伤后引起的深部同形反应受到关注。滑膜-附着点复合体在银屑病关节炎机制研究中扮演重要角色,在创伤及机械应力作用下,滑膜-附着点复合体部位可以发生深部同形反应,激活IL-23/Th17轴的先天性免疫反应,同适应性免疫反应相互作用,导致PsA发生。本文对近年来国内外机械应力相关微创伤在PsA的发生发展机制中的研究进展进行了综述。Psoriatic arthritis(PsA)can lead to joint deformities in severe cases,affecting patients daily life.In recent years,domestical and international progress has been made in the pathogenesis of PsA,especially focus on the deep koebner phenomenon triggered by local microtrauma to the joints.The Synovio-Entheseal Complex(SEC)plays an important role in the mechanistic studies of PsA.Due to trauma or mechanical stress,the deep Koebner response occurred at the SEC,activating the innate immune response through the IL-23/Th17 axis,which interacts with the adaptive immune responses,ultimately leading to the development of PsA.This paper reviews the update of mechanical stress related microtrauma in the pathogenesis and development of PsA in recent years both domestically and internationally.

关 键 词：银屑病关节炎 深部同形反应 机械应力 微创伤 附着点炎 

分 类 号：R684.3[医药卫生—骨科学] R758.63[医药卫生—外科学]