新疆维吾尔自治区人民医院输血科2011-2022年红细胞不规则抗体的回顾性分析  

A Retrospective Analysis of Irregular Erythrocyte Antibodies in the Blood Transfusion Department of People′s Hospital of Xinjiang Uygur Autonomous Region from 2011 to 2022

作　　者：王儒彬 李慧君 李菲[1] 陈伟[1] WANG Ru-Bin;LI Hui-Jun;LI Fei;CHEN Wei(Department of Blood Transfusion,People′s Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830001,Xinjiang Uygur Autonomous Region,China)

机构地区：[1]新疆维吾尔自治区人民医院输血科,新疆乌鲁木齐830001

出　　处：《中国实验血液学杂志》2025年第1期211-216,共6页Journal of Experimental Hematology

基　　金：新疆维吾尔自治区自然科学基金项目(2022D01C637)。

摘　　要：目的:回顾性分析2011年-2022年新疆维吾尔自治区人民医院输血科的红细胞不规则抗体分布情况以及红细胞不规则抗体与民族、性别、妊娠史、输血史的关系。方法:调取2011年-2022年本院的临床输血安全与血液管理软件中拟输血患者的不规则抗体筛查资料进行回顾性研究,分析2011年-2022年的红细胞不规则抗体分布情况,进一步分析民族、性别、妊娠史、输血史等因素与红细胞不规则抗体检出率的关系。结果:2011年-2022年的329 270例样本中红细胞不规则抗体阳性检出率为0.77%。在红细胞不规则抗体阳性样本中占比较高的3种血型依序是Rh血型(43.72%)、Lewis血型(9.90%)、MNS血型(6.44%)。Rh血型中抗-D、抗-E抗体在阳性样本中占比较高,分别为19.09%、16.06%,MNS血型中抗-M抗体在阳性样本中占比最高(5.46%),Lewis血型中抗Lea抗体在阳性样本中占比最高(8.80%)。汉族、回族、维吾尔族的红细胞不规则抗体检出率明显高于其他少数民族(P<0.001)。Rh血型系统红细胞不规则抗体阳性样本集中于汉族、维吾尔族。相比男性、无输血史、无妊娠史患者,女性患者及有输血史和妊娠史患者的红细胞不规则抗体检出率明显升高(P<0.01)。结论:输血前不规则抗体筛查以Rh血型系统抗体阳性为主,应加强各类Rh血型抗原筛查;对女性、有输血史和妊娠史的患者,以及少数民族患者应进行重点筛查。Objective:The distribution of irregular erythrocyte antibodies in the blood transfusion department of the People′s Hospital of Xinjiang Uygur Autonomous Region from 2011 to 2022 and the relationship between irregular erythrocyte antibodies and ethnicity,gender,pregnancy history,blood transfusion history were retrospectively analyzed.Methods:The irregular antibody screening data of patients who were proposed to receive blood transfusions in the clinical blood transfusion safety and blood management software of our hospital from 2011 to 2022 were collected for a retrospective study,and the distribution of irregular erythrocyte antibodies from 2011 to 2022 was analyzed.The relationship between ethnicity,gender,pregnancy history,blood transfusion history and the detection rate of irregular erythrocyte antibodies was further analyzed.Results:From 2011 to 2022,the positive detection rate of irregular erythrocyte antibodies in 329270 samples was 0.77%.Rh blood group(43.72%),Lewis blood group(9.90%)and MNS blood group(6.44%)accounted for the highest proportion of irregular erythrocyte antibody positive samples.In Rh blood group,the proportion of anti-D and anti-E in positive samples was the highest,with 19.09%and 16.06%,respectively.In MNS blood group,the proportion of anti-M in positive samples was the highest(5.46%).In Lewis blood group,the proportion of anti-Lea in positive samples was the highest(8.80%).Compared with other ethnic groups,the detection rates of irregular erythrocyte antibodies were significantly higher in Han,Hui and Uyghur ethnic groups(P<0.001).Irregular erythrocyte antibody positive samples in Rh blood group system were concentrated in Han and Uygur ethnic groups.Compared to males and patients without a history of blood transfusion and pregnancy,female patients and patients with a history of blood transfusion and pregnancy had significantly higher detection rates of irregulart erythrocyte antibodies(P<0.01).Conclusion:The results of irregular antibody screening before blood transfusion showed that

关 键 词：红细胞不规则抗体 输血 血型系统 民族 

分 类 号：R446.1[医药卫生—诊断学] R457.1[医药卫生—临床医学]