系统性免疫炎症指数对急性胰腺炎患者并发器官功能损伤的预测价值  

Predictive value of systemic immune inflammation index in patients with acute pancreatitis complicated with organ function impairment

作　　者：张洁[1] 罗小霞 余鸿[1] Zhang Jie;Luo Xiaoxia;Yu Hong(Department of Pancreatic Surgery,the First Affiliated Hospital of Xinjiang Medical University,Urumqi Xinjiang Uygur Autonomous Region 830054,China)

机构地区：[1]新疆医科大学第一附属医院胰腺外科,乌鲁木齐830054

出　　处：《中华普外科手术学杂志(电子版)》2025年第1期68-71,共4页Chinese Journal of Operative Procedures of General Surgery(Electronic Edition)

基　　金：新疆维吾尔自治区自然科学基金项目(2019D01C302)。

摘　　要：目的探讨系统性免疫炎症指数(SII)对急性胰腺炎患者并发器官功能损伤的预测价值。方法回顾性分析2020年1月至2023年6月168例急性胰腺炎患者资料,根据患者是否发生器官功能损伤,将患者分为损伤组(n=48例)和对照组(n=120例)。采用SPSS26.0统计软件分析数据,SII等计量资料以(x±s)表示,行独立样本t检验;采用受试者工作特色曲线(ROC)分析SII对急性胰腺炎器官功能损伤的预测价值。采用多因素Logistic回归分析探讨急性胰腺炎器官功能损伤的独立危险因素。P<0.05为差异有统计学意义(双侧)。结果与对照组比较,损伤组患者SII显著增高[(1012.2±281.2)vs.(662.0±167.9),P=0.000]。多因素Logistic回归分析显示SII>818.0、APPACHEⅡ评分>8.5和胰腺坏死感染是急性胰腺炎器官功能损伤的独立危险因素(P<0.05)。SII与急性胰腺炎患者Ranson评分、APPACHEⅡ评分、C反应蛋白、IL-6显著正相关(P<0.05)。SII、Ranson评分和APPACHEⅡ评分对急性胰腺炎器官功能损伤均有一定预测价值,其中SII的预测价值较高,曲线下面积为0.902(95%可信区间:0.846-0.958,P=0.000)。与对照组比较,损伤组患者机械通气率、持续性血液滤过率、外科引流率、院内死亡率均显著增高,住院时间延长(P<0.05)。结论SII增高是急性胰腺炎器官功能损伤的独立影响因素,可作为急性胰腺炎器官功能损伤的新型预测指标。Objective To investigate the predictive value of systemic immunoinflammatory index(SII)in patients with acute pancreatitis complicated with organ function injury.Methods The data of 168 patients with acute pancreatitis from January 2020 to June 2023 were retrospectively analyzed.According to whether the patients had organ function injury,the patients were divided into injury group(n=48 cases)and control group(n=120 cases).SPSS26.0 statistical software was used to analyze the data,SII and other measurement data were expressed as(x±s),and independent sample t test was performed.Receiver operating characteristic curve(ROC)was used to analyze the predictive value of SII in organ function injury in patients with acute pancreatitis.Multi-factor Logistics regression analysis was used to investigate the independent risk factors of organ function injury in patients with acute pancreatitis.When P<0.05,the difference was considered statistically significant(bilateral).Results Compared with the control group,SII was significantly increased in the injured group[(1012.2±281.2)vs.(662.0±167.9),P=0.000].Multi-factor Logistics regression analysis showed that SII>818.0,APPACHEⅡscore>8.5 and pancreatic necrosis infection were independent risk factors for organ function impairment in patients with acute pancreatitis(P<0.05).SII was significantly positively correlated with Ranson score,APPACHEⅡscore,C-reactive protein and IL-6 in patients with acute pancreatitis(P<0.05).SII,Ranson score and APPACHEⅡscore all have certain predictive value for organ function injury in patients with acute pancreatitis,among which SII has a higher predictive value,and the area under the curve is 0.902(95%confidence interval:0.846-0.958,P=0.000).Compared with the control group,the mechanical ventilation rate,continuous hemofiltration rate,surgical drainage rate and in-hospital mortality were significantly increased in the injured group,and the length of hospitalization was extended(P<0.05).Conclusion The increase of SII is an independent factor o

关 键 词：急性胰腺炎 系统性免疫炎症指数 器官功能损伤 

分 类 号：R657.5[医药卫生—外科学]