椎体软骨发育相关分子在先天性脊柱侧凸致病机制中的研究进展  

Research progress on vertebral cartilage development-related molecules in the pathogenesis of congenital scoliosis

作　　者：赵星辰[1] 叶勇裕 戴景兴 余涛 程星 尹东 欧阳钧 昌耘冰 陈崇 Zhao Xingchen;Ye Yongyu;Dai Jingxing;Yu Tao;Cheng Xing;Yin Dong;Ouyang Jun;Chang Yunbing;Chen Chong(Department of Spine Surgery,Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences),Southern Medical University,Guangzhou 510080,Guangdong,China;Guangdong Provincial Key Laboratory of Medical Biomechanics,Department of Anatomy,School of Basic Medical Sciences,Southern Medical University,Guangzhou 510515,Guangdong,China)

机构地区：[1]南方医科大学附属广东省人民医院(广东省医学科学院)脊柱外科,广东广州510080 [2]南方医科大学基础医学院人体解剖学教研室/广东省医学生物力学重点实验室,广东广州510515

出　　处：《中国临床解剖学杂志》2025年第1期112-115,共4页Chinese Journal of Clinical Anatomy

基　　金：国家自然科学基金(82102636);广东省自然科学基金(2022A1515012557);广州市科技计划基金(202103000053,2023A04J0500)。

摘　　要：椎体起源于体节,是脊柱重要组成部分,其发育异常与先天性脊柱侧凸(Congenital scoliosis,CS)等多种疾病相关。在人类胚胎发育时期,体节来源的间充质细胞分化为软骨细胞进而骨化形成椎体,这一过程中椎体软骨的发育由多种信号分子协同调控。然而,有关椎体软骨发育过程与CS致病因素的关联尚无全面综述,因此本文旨在对椎体软骨发育和CS相关的分子机制进行总结,阐明CS致病因素背后的分子调控,以期为临床寻找更好的治疗CS的方法提供理论依据和研究方向。The vertebral body originates from the body segments and is an important part of spine.Its developmental abnormalities are related to various diseases such as congenital scoliosis(CS).During human embryonic development,mesenchymal cells derived from somites differentiate into vertebral cartilage cells and then ossify to form vertebral bodies.During this process,vertebral cartilage development is coordinated and regulated by a variety of molecular signals.However,there is no comprehensive review on the relationship between the development process of vertebral cartilage and the pathogenic factors of CS.Therefore,we summarized the molecular mechanisms related to the development of vertebral cartilage and CS,and elucidated the molecular regulation behind the pathogenic factors of CS,in order to find clinical better methods to treat CS provide theoretical basis and research direction.

关 键 词：椎体 软骨发育 先天性脊柱侧凸 信号分子 致病因素 

分 类 号：R687[医药卫生—骨科学]