拉贝洛尔联合硫酸镁与硝苯地平在治疗妊娠期高血压疾病中的效果及对母婴预后的影响研究  

Efficacy of Labetalol Combined with Magnesium Sulfate and Nifedipine in the Treatment of Hypertensive Diseases During Pregnancy and the Influence on Maternal and Infant Prognosis

作　　者：刘全燕 LIU Quanyan(Department of Obstetrics,Shouguang People's Hospital,Weifang,Shandong,262700,China)

机构地区：[1]山东省寿光市人民医院产科,山东潍坊262700

出　　处：《中外医疗》2024年第35期31-35,共5页China & Foreign Medical Treatment

摘　　要：目的探讨拉贝洛尔联合硫酸镁与硝苯地平在治疗妊娠期高血压疾病(hypertensive disorders of pregnancy,HDP)中的效果及对母婴预后的影响。方法随机选取2019年7月—2024年3月山东省寿光市人民医院收治的80例HDP患者为研究对象,根据不同用药方案分为常规组、探究组,每组40例。常规组接受拉贝洛尔联合硫酸镁治疗,探究组在此基础上应用硝苯地平治疗,对比两组血压水平、血管内皮功能、凝血功能、不良反应发生率、不良母婴结局情况。结果治疗后,两组血压水平优于治疗前,探究组舒张压、收缩压均低于常规组,血压达标时间短于常规组,差异均有统计学意义(P均<0.05)。治疗后,两组血管内皮功能优于治疗前,探究组血管内皮功能优于常规组,差异均有统计学意义(P均<0.05)。治疗后,两组凝血功能优于治疗前,探究组凝血功能优于常规组,差异均有统计学意义(P均<0.05)。两组不良反应总发生率对比,差异无统计学意义(P>0.05)。探究组不良母婴结局发生率5.00%(2/40)低于常规组的20.00%(8/40),差异有统计学意义(χ^(2)=4.114,P<0.05)。结论联合使用拉贝洛尔、硫酸镁和硝苯地平在治疗HDP方面表现出较好的治疗效果,能有效地控制患者的血压,对血管内皮功能和凝血功能有改善作用,并降低不良母婴结局的发生率。Objective To investigate the effect of labetalol combined with magnesium sulfate and nifedipine in the treatment of hypertensive disorders of pregnancy(HDP)and its effect on maternal and infant prognosis.Methods A total of 80 patients with HDP admitted to Shouguang People's Hospital of Shandong Province from July 2019 to March 2024 were randomly selected as the research objects.According to different medication regimens,they were divided into routine group and inquiry group,with 40 cases in each group.The routine group was treated with labetalol combined with magnesium sulfate,and the inquiry group was treated with nifedipine on this basis.The blood pressure level,vascular endothelial function,coagulation function,the incidence of adverse reactions and adverse maternal and infant outcomes were compared between the two groups.Results After treatment,the blood pressure levels of the two groups were better than those before treatment,the diastolic blood pressure and systolic blood pressure of the inquiry group were lower than those of the routine group,and the time of blood pressure reaching the standard was shorter than that of the routine group,the differences were statistically significant(all P<0.05).After treatment,the vascular endothelial function of the two groups was better than that before treatment,and the vascular endothelial function of the inquiry group was better than that of the routine group,the differences were statistically significant(all P<0.05).After treatment,the coagulation function of the two groups was better than that before treatment,and the coagulation function of the inquiry group was better than that of the routine group,the differences were statistically significant(all P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).The incidence of adverse maternal and infant outcomes in the inquiry group was 5.00%(2/40)lower than 20.00%(8/40)in the routine group,and the difference was statistically significant(χ^(2)=4.114,P<0.05

关 键 词：妊娠期高血压疾病 拉贝洛尔 硫酸镁 硝苯地平 母婴预后 

分 类 号：R714.246[医药卫生—妇产科学]