微型化生物医学光学成像系统  

Miniaturized biomedical optical imaging systems

作　　者：苏德尔 高伟达[2] 王新伟 李浩宇[1] 刘文灏 郭长亮 赵唯淞 Su Deer;Gao Weida;Wang Xinwei;Li Haoyu;Liu Wenhao;Guo Changliang;Zhao Weisong(Innovation Photonics and Imaging Center,School of Instrumentation Science and Engineering,Harbin Institute of Technology,Harbin,Heilongjiang 150080,China;Department of Neurosurgery,The Second Affiliated Hospital of Harbin Medical University,Harbin,Heilongjiang 150086,China;School of Instrumentation Science and Engineering,Harbin Institute of Technology,Harbin,Heilongjiang 150001,China;Beijing Institute of Collaborative Innovation,Beijing 100094,China;State Key Laboratory of Membrane Biology,Beijing Key Laboratory of Cardiometabolic Molecular Medicine,Institute of Molecular Medicine,National Biomedical Imaging Center,School of Future Technology,Peking University,Beijing 100871,China)

机构地区：[1]哈尔滨工业大学先进光电成像技术研究室,黑龙江哈尔滨150080 [2]哈尔滨医科大学附属第二医院神经外科室,黑龙江哈尔滨150086 [3]哈尔滨工业大学仪器科学与工程学院,黑龙江哈尔滨150001 [4]北京协同创新研究院,北京100094 [5]北京大学未来技术学院国家生物医学成像中心分子医学研究所膜生物学国家重点实验室、代谢及心血管分子医学北京市重点实验室,北京100871

出　　处：《光电工程》2024年第12期1-26,共26页Opto-Electronic Engineering

基　　金：国家自然科学基金资助项目(32422052,62305083,T2222009);中国国家重点研发计划(2022YFC3400600);中国科协青年托举工程(2023QNRC001);中央高校基本科研业务费专项资金资助(HIT-BRET-2022013)。

摘　　要：生物医学光学成像技术因其高分辨率和无辐射毒性的优势成为了连接基础科学研究与临床应用的桥梁,对推动医学进步和提高公共健康水平起到了重要作用。然而,生物医学光学成像系统往往需要将光、机、电、控元件整合为一体,导致设备笨重且昂贵,难以满足人们对即时诊断和体内微创高分辨率成像的需求。随着元件加工手段的进步和新式技术的引入,微型化生物医学光学成像系统的设计制造逐渐开始成为了新的研究热点之一。本文分别对用于体外和体内检测的微型化生物医学光学成像系统的基本原理、关键技术以及在临床中的具体应用进行了深入地综述和总结,最后展望了该领域的发展方向。Biomedical optical imaging techniques have become essential for bridging fundamental scientific research and clinical applications,owing to their high resolution and absence of radiation toxicity.These advancements are crucial for driving medical innovation and improving public health outcomes.However,the integration of optical,mechanical,electrical,and control components in biomedical optical imaging systems often leads to bulky and costly equipment.This complexity limits their capacity to fulfill the growing demand for point-ofcare testing(POCT)and high-resolution,minimally invasive imaging.Recent advancements in component fabrication techniques and the emergence of new technologies have positioned the design and manufacture of miniaturized biomedical optical imaging systems as a significant area of research.This review comprehensively addresses the fundamental principles,key technologies,and specific clinical applications of these systems for both in vitro and in vivo detection.Lastly,we provide insights into potential future directions in this evolving field.

关 键 词：生物医学 光学成像系统 微型化 内窥成像系统 

分 类 号：R318.51[医药卫生—生物医学工程]