肥胖与认知功能下降相关性的脑MRI研究进展  

Advances in brain MRI research on the correlation between obesity and cognitive decline

作　　者：蒋春荣 梁玲艳 刘思球 雷淼 邓德茂 JIANG Chunrong;LIANG Lingyan;LIU Siqiu;LEI Miao;DENG Demao(Graduate School of Guangxi University of Traditional Chinese Medicine,Nanning 530001,China;Department of Radiology,Guilin People's Hospital,Guilin 541000,China;Departmen of Radiology,Guangxi Zhuang Autonomous Region People's Hospital,Nanning 530021,China)

机构地区：[1]广西中医药大学研究生院,南宁530001 [2]桂林市人民医院放射科,桂林541000 [3]广西壮族自治区人民医院放射科,南宁530021

出　　处：《磁共振成像》2025年第1期170-174,186,共6页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金项目(编号:82060315、82102032);广西青年科学基金项目(编号:2022JJB140204)。

摘　　要：肥胖是多种疾病的高危因素,也是全球死亡的独立危险因素。认知功能的六大关键领域包括复杂注意力、执行功能、学习与记忆、语言、感知运动控制以及社会认知。认知功能下降是一个常见且令人恐惧的问题,其诱因很多,国内外研究表明肥胖可引起认知功能下降,涉及奖赏和动机、感觉运动、学习记忆以及认知控制等多个方面。肥胖可引起脑的结构、功能等改变,进而导致认知功能下降,但其作用机制尚不明确。MRI已广泛应用于神经、精神疾病的研究,本综述分析了肥胖对认知功能的影响,概述其潜在机制;讨论并总结了肥胖引起认知功能下降的脑MRI特点,从脑结构、功能、代谢、血流灌注等方面揭示了其相关性,为今后预防和治疗肥胖患者的认知功能下降提供方向。Obesity is a high risk factor for many diseases and an independent risk factor for death worldwide.The six key areas of cognitive function include complex attention,executive function,learning and memory,language,sensorimotor control,and social cognition.Studies at home and abroad have shown that obesity causes cognitive function decline,involving reward and motivation,sensorimotor,memory and cognitive control.Obesity can cause changes in brain structure and function,and then lead to cognitive function decline,but its mechanism is still unclear.MRI has been widely used in the study of neurological and psychiatric diseases.This review analyzes the effects of obesity on cognitive function and summarizes its potential mechanisms.This paper discusses and summarizes the brain MRI characteristics of obesity induced cognitive function decline,and reveals its correlation from the aspects of brain structure,function,metabolism,blood perfusion,etc.,providing directions for the prevention and treatment of cognitive function decline in obese patients in the future.

关 键 词：肥胖 认知功能 磁共振成像 脑结构 脑功能 

分 类 号：R445.2[医药卫生—影像医学与核医学] R745.1[医药卫生—诊断学]