抽动秽语综合征多模态磁共振成像研究近况与展望  

Recent progress and prospect of multimodal magnetic resonance imaging in Gilles de la Tourettesyndrome

作　　者：刘潇[1,2] 郭祥发 李晓陵 王杨[4] 高胜兰 魏泽宜 LIU Xiao;GUO Xiangfa;LI Xiaoling;WANG Yang;GAO Shenglan;WEI Zeyi(Department of Pediatrics,the First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040,China;Graduate School,Heilongjiang University of Chinese Medicine,Harbin 150040,China;Department of Medical Imaging,the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150001,China;Department of CT Magnetic Resonance,the First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040,China;Department of Radiology,Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China)

机构地区：[1]黑龙江中医药大学附属第一医院儿科,哈尔滨150040 [2]黑龙江中医药大学研究生院,哈尔滨150040 [3]黑龙江中医药大学附属第二医院医学影像科,哈尔滨150001 [4]黑龙江中医药大学附属第一医院CT磁共振科,哈尔滨150040 [5]上海交通大学医学院附属新华医院放射科,上海200092

出　　处：《磁共振成像》2025年第1期175-180,192,共7页Chinese Journal of Magnetic Resonance Imaging

基　　金：黑龙江省中医药科研项目(编号:ZHY2023-054);哈尔滨市科技计划项目(编号:2023ZCZJNS063)。

摘　　要：抽动秽语综合征(Gilles de la Tourette syndrome,GTS)属于儿童期神经发育障碍类疾病,少数病例延至成年期;GTS典型征象包括不自主运动及发声抽动,多伴随注意缺陷多动障碍等,严重影响患者生存质量。GTS起病多与皮质-纹状体-丘脑-皮质(cortico-striato-thalamo-cortical,CSTC)环路功能异常关联。目前,基于MRI对GTS发病、先兆冲动、抽动程度及社会认知诸方面的机制研究,已逐渐成为业内热点;结构和功能MRI对GTS感觉、运动、情感、认知等相关脑区的激活及网络改变,能够予以揭示。笔者围绕近年内基于体素形态学分析(voxel-based morphometry,VBM)、弥散张量成像(diffusion tensor imaging,DTI)、功能MRI(functional MRI,fMRI)、磁共振波谱(magnetic resonance spectroscopy,MRS)等不同模态成像的相关文献,进行归纳总结,为疾病早期识别及后续的深入探索提供帮助。Gilles de la Tourette syndrome(GTS)is a category of childhood neurodevelopmental disorders,with a few cases extending to adulthood.Typical signs of GTS include involuntary movement and vocal tic,often accompanied by attention deficit hyperactivity disorder,which seriously affects the quality of life of patients.The onset of GTS is associated with abnormal circuit function of cortico-striato-thalamo-cortical(CSTC).At present,the research on the mechanism of GTS pathogenesis,premonitory impulse,tic degree and social cognition based on MRI has gradually become a hot topic in the industry.Structural and functional MRI can reveal the activation and network changes of GTS sensory,motor,emotional,cognitive and other related brain areas.The author has reviewed recent literature on various modalities of imaging,including voxel-based morphometry(VBM),diffusion tensor imaging(DTI),functional MRI(fMRI),and magnetic resonance spectroscopy(MRS),and summarized the findings to help with early disease identification and further exploration.

关 键 词：抽动秽语综合征 磁共振成像 结构磁共振成像 弥散张量成像 功能磁共振成像 磁共振波谱 

分 类 号：R445.2[医药卫生—影像医学与核医学] R749.94[医药卫生—诊断学]