免疫代谢对脓毒症时巨噬细胞功能调节的研究进展  

Progress in the immunometabolism in the regulation of macrophage function in sepsis

作　　者：卢莹莹 白艳 李菲 饶竹青[1] Lu Yingying;Bai Yan;Li Fei;Rao Zhuqing(Department of Anesthesiology,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,Jiangsu,China)

机构地区：[1]南京医科大学第一附属医院麻醉科,江苏南京210029

出　　处：《中华危重病急救医学》2024年第12期1321-1324,共4页Chinese Critical Care Medicine

基　　金：国家自然科学基金(81901628)。

摘　　要：巨噬细胞广泛分布于机体外周血、肺、肝、脑、肾、皮肤、睾丸、血管内皮细胞等部位,其作为固有免疫的前哨细胞,在脓毒症的发生发展中起重要作用。近年来,免疫代谢研究揭示了脓毒症时巨噬细胞特定代谢途径与其功能表型之间的复杂联系,脓毒症促炎反应阶段巨噬细胞以糖酵解为主要特征,而免疫抑制阶段更依赖于线粒体的氧化磷酸化(OXPHOS)。因此,本文对脓毒症时巨噬细胞代谢相关信号通路、分子、酶及代谢中间体如何塑造巨噬细胞功能状态进行综述,以期找到调节机体免疫状态的关键靶点。Macrophages are widely distributed in peripheral blood,lungs,liver,brain,kidneys,skin,testes,vascular endothelial cells,and other parts of the body.As sentinel cells of innate immunity,they play an important role in the occurrence and development of sepsis.Recent research in immune metabolism has revealed the complicated relationship between specific metabolic pathways of macrophages and their phenotype and function in sepsis.During the pro-inflammatory phase of sepsis,macrophages are characterized by glycolysis,while in the immunosuppressive phase,they rely more on mitochondrial oxidative phosphorylation(OXPHOS).Hence,this review describes how macrophages metabolism related signaling pathways,molecules,enzymes and metabolic intermediates determine their phenotype and function to find critical targets which regulate the body immune status in sepsis.

关 键 词：脓毒症 巨噬细胞 免疫代谢 极化 

分 类 号：R459.7[医药卫生—急诊医学]