Fecal microbiota transplants in pediatric autism: opportunities and challenges  

作　　者：Jian Wang Rong Yang Hui Zhong Yan-Jun Liu 

机构地区：[1]Department of Pediatrics,Shanghai Tenth People’s Hospital,Tongji University School of Medicine,Shanghai,China

出　　处：《World Journal of Pediatrics》2024年第12期1201-1204,共4页世界儿科杂志(英文版)

基　　金：supported by the Project of the National Natural Science Foundation of China(grant number:82070823).

摘　　要：Autism spectrum disorder(ASD)is a prevalent pediatric neurodevelopmental disorder marked by challenges in social communication and repetitive behaviors.The increasing incidence of ASD has made it a signifcant global concern,profoundly impacting families and impeding the developmental progress of afected children[1].Beyond the core neurodevelopmental issues,individuals with ASD frequently experience a range of co-occurring symptoms,including sleep disorders,seizures,obesity,malnutrition,and gastrointestinal issues[2,3].Gastrointestinal symptoms are particularly common,afecting nearly 50%of children with ASD,and typically manifest as diarrhea,constipation,or abdominal pain[4].Due to the complexity of ASD and the limited efcacy of current treatments,clinicians and researchers have been exploring new therapy approaches.These include behavioral interventions and experimental therapies,such as oral probiotics,digestive enzyme supplementation,diet intervention,N-acetylcysteine,and sensory integration therapies[5–7].However,there are currently no consistently efective treatments for managing ASD.

关 键 词：PEDIATRIC typically CHALLENGES 

分 类 号：R54[医药卫生—心血管疾病]