阿奇霉素颗粒口服联合哌拉西林他唑巴坦治疗对社区获得性肺炎患儿炎症介质水平的影响  

Effect of Azithromycin Granules combined with Piperacillin Tazobactam on inflammatory mediators in children with community-acquired pneumonia

作　　者：卢文华 童童 杨泉 LU Wenhua;TONG Tong;YANG Quan(Department of Pediatric Medicine,Shangrao Maternal and Child Health Hospital,Jiangxi Province,Shangrao334000,China;Department of Emergency,Shangrao Maternal and Child Health Hospital,Jiangxi Province,Shangrao334000,China)

机构地区：[1]江西省上饶市妇幼保健院儿内科,江西上饶334000 [2]江西省上饶市妇幼保健院急诊科,江西上饶334000

出　　处：《中国当代医药》2024年第36期88-91,共4页China Modern Medicine

基　　金：江西省卫生健康委科技计划项目(202410972)。

摘　　要：目的 探讨阿奇霉素颗粒口服联合哌拉西林他唑巴坦治疗对社区获得性肺炎(CAP)患儿的影响。方法 选取2022年1月至2023年12月上饶市妇幼保健医院收治的68例CAP患儿为研究对象,按照随机数字表法分为观察组(34例)和对照组(34例)。对照组予以哌拉西林他唑巴坦治疗,观察组于对照组基础上加用阿奇霉素颗粒口服。比较两组炎症因子[超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白介素-8(IL-8)、白介素-6(IL-6)、降钙素原(PCT)]、体征改善时间、治疗总有效率及不良反应。结果 观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05);观察组的hs-CRP、TNF-α、IL-8、IL-6、PCT水平低于对照组,差异有统计学意义(P<0.05);观察组的胸部X线炎症明显吸收时间、血常规恢复正常时间、肺啰音消失时间、咳痰消失时间、发热消失时间均短于对照组,差异有统计学意义(P<0.05);两组患者的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论 在CAP患儿中应用阿奇霉素颗粒口服联合哌拉西林他唑巴坦治疗的疗效肯定,可促进患儿体内炎症介质水平降低,缩短体征及症状改善时间,且安全性高。Objective To explore the influence of oral Azithromycin Granules and Piperacillin Tazobactam on children with community-acquired pneumonia(CAP).Methods Sixty-eight children with CAP admitted to Shangrao Maternal and Child Health Hospital from January 2022 to December 2023 were selected as the study objects,and were divided into observation group(34 cases)and control group(34 cases)according to random number table method.The control group took Piperacillin Tazobactam,while the observation group orally took Azithromycin Granules on the basis of the control group.The inflammatory factors(hypersensitive C-reactive protein[hs-CRP],tumor necrosis factor-α[TNF-α],interleukin-8[IL-8],leukocyte-6[IL-6],procalcitonin[PCT]),the improvement time of signs,the total effective rate of treatment and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).The levels of hs-CRP,TNF-α,IL-8,IL-6 and PCT in observation group were lower than those in control group,and the differences were statistically significant(P<0.05).The obvious absorption time of chest X-ray inflammation,the time of normal blood routine,the time of disappearance of lung rales,the time of disappearance of sputum and the time of disappearance of fever in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Azithromycin Granules combined with Piperacillin Tazobactam is effective in the treatment of children with CAP,which can reduce the levels of inflammatory mediators in the body,shorten the time for improvement of signs and symptoms,and has high safety.

关 键 词：社区获得性肺炎 哌拉西林他唑巴坦 阿奇霉素 炎症因子 

分 类 号：R563[医药卫生—呼吸系统]