间充质干细胞来源外泌体治疗类风湿关节炎的研究进展  

Research progress on mesenchymal stem cell-derived exosome in the treatment of rheumatoid arthritis

作　　者：赵行 宋宗键 苏梦焱 刘康楠 吴蓓 邹晨冉 展俊平[2] 周子朋[2] ZHAO Hang;SONG Zongjian;SU Mengyan;LIU Kangnan;WU Bei;ZOU Chenran;ZHAN Junping;ZHOU Zipeng(College of Orthopedics,Henan University of Chinese Medicine,Henan Province,Zhengzhou 450003,China;Department of Rheumatology,Henan Provincial Hospital of Traditional Chinese Medicine,Henan Province,Zhengzhou 450003,China)

机构地区：[1]河南中医药大学骨伤学院,河南郑州450003 [2]河南省中医院风湿病科,河南郑州450003

出　　处：《中国医药导报》2025年第3期63-68,共6页China Medical Herald

基　　金：国家自然科学基金面上项目(81874456);国家中医临床研究基地科研专项课题(2021JDZX2123);第七批全国老中医药专家学术经验继承工作指导项目(国中医人教函〔2022〕76号);河南省中医药科学研究专项重点课题(2024 ZY1011);河南省高等学校重点科研项目(22B360006)。

摘　　要：类风湿关节炎(RA)是一种主要影响关节及滑膜的系统性炎症性疾病,现有治疗手段效果有限且存在多种副作用。间充质干细胞来源外泌体(MSC-Exo),作为一种无细胞治疗方式,因其具备良好的生物相容性、低毒性及低免疫原性等优点,在RA治疗领域受到广泛关注。MSC-Exo可通过抑制炎症反应、抑制RA成纤维样滑膜细胞的增殖和侵袭、抑制血管生成的激活、调节辅助性T细胞亚群的占比等方式发挥对RA的治疗作用。本文对间充质干细胞与MSC-Exo的特征、MSC-Exo治疗RA的机制进行综述,以期为后续研究提供参考。Rheumatoid arthritis(RA)is a systemic inflammatory disease that primarily affects joints and synovium,existing treatment methods have limited effectiveness and multiple side effects.Mesenchymal stem cell-derived exosome(MSC-Exo),as a cell-free therapy method,have received widespread attention in the field of RA treatment due to their excellent biocompatibility,low toxicity,and low immunogenicity.MSC-Exo can exert therapeutic effects on RA by inhibiting inflammatory responses,suppressing proliferation and invasion of RA fibroblast like synovial cells,inhibiting the activation of angiogenesis,and regulating the proportion of helper T cell subsets.This article reviews characteristics of mesenchymal stem cells and MSC-Exo,mechanism of MSC-Exo in the treatment of RA,in order to provide reference for future research.

关 键 词：间充质干细胞 外泌体 类风湿关节炎 

分 类 号：R493.21[医药卫生—康复医学]