1918株铜绿假单胞菌临床分布特征及耐药性分析  

Clinical distribution characteristics and drug resistance analysis of 1918 strains of Pseudomonas aeruginosa

作　　者：赵红燕[1] 卢赞[1] 李代碧 李春付 ZHAO Hong-yan;LU Zan;LI Dai-bi(Department of Clinical Laboratory,kunming First People's Hospital,Yunnan Kunming 650011)

机构地区：[1]昆明市第一人民医院检验科,云南昆明650011

出　　处：《医学检验与临床》2024年第12期9-12,21,共5页Medical Laboratory Science and Clinics

基　　金：昆明市卫生健康委员会卫生科研项目,项目编号:2022-11-01-022。

摘　　要：目的:回顾性分析1918株铜绿假单胞菌(PA)临床分布特征及耐药性,为临床合理使用抗生素提供参考依据。方法:收集某院2016年-2022年分离的1918株铜绿假单胞菌,对其临床分布特征和耐药性进行分析。结果:1918株铜绿假单胞菌主要来源于痰液(1555株,81.1%),其次是尿液(131株,6.8%)和分泌物(75株,3.9%);科室分离率前三位分别为呼吸内科(758株,39.6%)、重症医学科(322株,16.9%)、老年病科(230株,12%);平均耐药率最高的是亚胺培南(20.9%),其次是氨曲南(19.5%)和美罗培南(18%),最低的是多粘菌素B(1%);肝胆胰科和重症医学科耐药率相对其他科室较高,呼吸内科耐药率相对较低。结论:铜绿假单胞菌易感染呼吸道,呼吸内科、重症医学科、老年病科是主要检出科室,不同科室间耐药率不同,临床应根据药敏结果合理使用抗生素,加强重点科室耐药性监测和感染防控,减低耐药菌的流行。Objective:To retrospectively analyze the clinical distribution characteristics and drug resistance of Pseudomonas aeruginosa strain 1918,so as to provide evidence for rational use of antibiotics in clinic.Methods:1918 strains of Pseudomonas aeruginosa isolated from a hospital from 2016 to 2022 were collected,and their clinical distribution characteristics and drug resistance were analyzed.Results:P.aeruginosa of 1918 strain was mainly derived from sputum(1555 strains,81.1%),followed by urine(131 strains,6.8%)and secretion(75 strains,3.9%),The top three separation rates of departments were respiratory medicine(758 strains,39.6%),intensive care medicine(322 strains,16.9%)and geriatrics(230 strains,12%).The average drug resistance rate of imipenem was the highest(20.9%),followed by aztronam(19.5%)and meropenem(18%),and polymyxin B was the lowest(1%).The drug resistance rate of hepatobiliary and intensive care departments was higher than that of other departments,and the drug resistance rate of respiratory department was lower.Conclusion:Pseudomonas aeruginosa is easy to infect respiratory tract.Respiratory medicine,intensive care medicine and geriatrics department are the main detectable departments,and the drug resistance rate is different among different departments.Antibiotics should be used rationally according to drug susceptibility results,and drug resistance monitoring and infection prevention and control should be strengthened in key departments to reduce the prevalence of drug-resistant bacteria.

关 键 词：铜绿假单胞菌 临床分布 耐药率 

分 类 号：R44[医药卫生—诊断学]