益气维血胶囊联合右旋糖酐铁治疗妊娠期缺铁性贫血孕妇的临床疗效  

Clinical Efficacy of Yiqi Weixue Capsule Combined with Ferric Carboxymaltose in the Treatment of Iron Deficiency Anemia during Pregnancy

作　　者：胡芳 王静 HU Fang;WANG Jing(Department of Maternity Care,Wuyishan Maternal and Child Health Hospital,Wuyishan Fujian 354300)

机构地区：[1]武夷山市妇幼保健院妇保科,福建武夷山354300 [2]武夷山市妇幼保健院妇产科,福建武夷山354300

出　　处：《医学临床研究》2024年第12期1916-1919,共4页Journal of Clinical Research

摘　　要：【目的】探讨益气维血胶囊联合右旋糖酐铁治疗妊娠期缺铁性贫血孕妇的疗效。【方法】选取2020年1月至2023年1月在本院诊治的97例妊娠期缺铁性贫血孕妇,采用摸球法随机分为观察组(采用益气维血胶囊联合右旋糖酐铁治疗,n=48)和对照组(采用右旋糖酐铁治疗,n=49)。比较两组孕妇治疗1个月后的临床疗效、治疗期间不良反应发生率、不良妊娠结局发生率及治疗前后的铁代谢指标[血清铁(SI)、铁调素(Hepcidin)、铁蛋白(SF)、铁蛋白饱和度(TSAT)、转铁蛋白(TRF)、可溶性转铁蛋白受体(sTfR)、铁幼素(FJV)、膜铁转运蛋白(FPN)]、红细胞[血红蛋白(HGB)、平均红细胞血红蛋白量(MCH)、平均红细胞血红蛋白浓度(MCHC)、平均红细胞体积(MCV)、红细胞比容(HCT)]水平。【结果】治疗后,观察组总有效率和SI、SF、TSAT、FJV水平高于对照组,Hepcidin、TRF、sTfR、FPN水平以及不良妊娠结局发生率低于对照组(P<0.05),HGB、MCH、MCHC、MCV、HCT水平均高于对照组(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。【结论】联合疗法治疗妊娠期缺铁性贫血孕妇的效果显著,可有效提升铁代谢指标和红细胞指标水平,改善孕妇贫血状况,降低不良妊娠结局发生率,且安全性良好。【Objective】To explore the clinical efficacy of Yiqi Weixue Capsule combined with Ferric Carboxymaltose in treating iron deficiency anemia during pregnancy.【Methods】A total of 97 pregnant women with iron deficiency anemia,who were treated in our hospital between January 2020 and January 2023,were randomly divided into two groups using the method of drawing lots.The observation group(n=48)was treated with Yiqi Weixue Capsule combined with Ferric Carboxymaltose,while the control group(n=49)was treated with Ferric Carboxymaltose only.The clinical efficacy,incidence of adverse reactions,incidence of adverse pregnancy outcomes,and iron metabolism indicators[hepcidin(Hepcidin),serum iron(SI),ferritin(SF),transferrin saturation(TSAT),transferrin(TRF),soluble transferrin receptor(sTfR),ferroportin(FPN),ferritin-like protein(FJV)]and red blood cell parameters[hemoglobin(HGB),mean corpuscular hemoglobin(MCH),mean corpuscular hemoglobin concentration(MCHC),mean corpuscular volume(MCV),hematocrit(HCT)]were compared between the two groups after 1 month of treatment.【Results】After treatment,the observation group showed a higher total effective rate and higher levels of SI,SF,TSAT,and FJV compared to the control group.The levels of Hepcidin,TRF,sTfR,FPN,and the incidence of adverse pregnancy outcomes in the observation group were lower than those in the control group(P<0.05).The levels of HGB,MCH,MCHC,MCV,and HCT in the observation group were higher than those in control group(P<0.05).The incidence of adverse reactions between the two groups was not significantly different(P>0.05).【Conclusion】The combined therapy is highly effective in treating pregnant women with iron deficiency anemia,significantly improving iron metabolism and red blood cell parameters,alleviating anemia,and reducing adverse pregnancy outcomes.It is safe treatment.

关 键 词：贫血 缺铁性 孕妇 铁右旋糖酐复合物 中西药合用 治疗结果 

分 类 号：R556.3[医药卫生—血液循环系统疾病]