地舒单抗联合鲑降钙素注射液治疗糖皮质激素性骨质疏松症患者的临床疗效  

Clinical Study on Glucocorticoid-Induced Osteoporosis Treated with Desumab Combined with Calcitonin Injection

作　　者：林玲 吴世勇 LIN Ling;WU Shiyong(Department of Pharmacy,Jiangle County Hospital,Sanming Fujian 353300)

机构地区：[1]将乐县总医院药剂科,福建三明353300 [2]将乐县总医院骨科,福建三明353300

出　　处：《医学临床研究》2024年第12期1927-1930,共4页Journal of Clinical Research

摘　　要：【目的】探讨地舒单抗联合鲑降钙素注射液治疗糖皮质激素性骨质疏松症(GIOP)患者的临床疗效。【方法】选取2021年7月至2023年1月本院收治的204例GIOP患者,按照随机数字表法分为对照组(n=103)和观察组(n=101)。对照组在常规治疗基础上加用鲑降钙素注射液治疗,观察组在对照组基础上加用地舒单抗注射液治疗,两组均治疗12个月。比较两组临床疗效、药物不良反应总发生率及治疗前后骨密度、疼痛情况[采用视觉模拟疼痛量表(visual analogue scale,VAS)评分评估]、骨代谢标志物[骨钙素(N-MID)、Ⅰ型前胶原N端肽(PⅠNP)、β-胶原特殊序列(β-CTX)、碱性磷酸酶(BAP)、降钙素(CT)]、功能障碍情况[采用Oswestry功能障碍指数(ODI)评分评估]。【结果】治疗后,观察组L 2~4、股骨颈骨密度及BAP水平均高于对照组,β-CTX、N-MID、PⅠNP、CT均低于对照组,差异均有统计学意义(P<0.05)。治疗6个月、治疗12个月后,观察组VAS、ODI评分均低于对照组(P<0.05)。观察组总有效率(91.09%)高于对照组(80.58%)(P<0.05)。两组药物不良反应总发生率比较,差异无统计学意义(P>0.05)。【结论】地舒单抗联合鲑降钙素注射液治疗GIOP患者效果显著,可增加患者骨密度,减轻疼痛及功能障碍,改善骨代谢指标,且安全可靠。【Objective】To investigate the clinical efficacy of disumab combined with salmon calcitonin injection in the treatment of glucocorticoid-induced osteoporosis(GIOP).【Methods】A total of 204 patients with GIOP admitted to our hospital from July 2021 to January 2023 were selected and divided into the control group(n=103)and the observation group(n=101)according to random number table method.The control group was treated with calcitonin injection on the basis of conventional treatment,while the observation group was treated with sulizumab injection on the basis of control group.Both groups were treated for 12 months.The clinical efficacy,total incidence of adverse drug reactions,bone mineral density[osteocalcin(N-MID),procollagen typeⅠN-terminal peptide(PⅠNP),β-collagen special sequence(β-CTX),alkaline phosphatase(BAP),calcitonin(CT)],and dysfunction[assessed by Oswestry Disability Index(ODI)score]and pain[visual analogue pain scale(VAS)]before and after treatment were compared between the two groups.【Results】After treatment,L 2~4,bone mineral density and BAP levels of femoral neck in observation group were higher than those in control group,whileβ-CTX,N-MID,PⅠNP and CT were lower than those in control group,with statistical significance(P<0.05).After 6 months and 12 months of treatment,VAS and ODI scores in observation group were lower than those in control group(P<0.05).The total effective rate of observation group(91.09%)was higher than that of control group(80.58%)(P<0.05).There was no significant difference in the total incidence of adverse drug reactions between the two groups(P>0.05).【Conclusion】Disumab combined with calcitonin injection is effective in the treatment of GIOP patients,which can increase bone mineral density,relieve pain and dysfunction,improve bone metabolism indexes,and is safe and reliable.

关 键 词：骨质疏松 糖皮质激素类 抗体 单克隆 降钙素 治疗结果 

分 类 号：R681.4[医药卫生—骨科学]