肾功能指标在慢性阻塞性肺病患者外周血中的水平变化及其意义  

The Expression Level and Significance of Renal Function Index in Peripheral Blood of Patients with Chronic Obstructive Pulmonary Disease

作　　者：洪卫煌 张燮颖 麻益龙 HONG Weihuang;ZHANG Xieying;MA Yilong(Department of Respiratory and Critical Care Medicine,Longyan People's Hospital,Longyan Fujian 364000)

机构地区：[1]龙岩人民医院呼吸与危重症医学科,福建龙岩364000

出　　处：《医学临床研究》2024年第12期1934-1937,共4页Journal of Clinical Research

摘　　要：【目的】探讨肾功能指标[尿酸(UA)、肌酐(Cr)、胱抑素C(cys C)、B型脑钠肽(BNP)]在慢性阻塞性肺病(COPD)患者外周血中的水平变化及其意义。【方法】选取2020年5月至2022年6月本院收治的96例COPD患者,其中急性发作期COPD患者45例(急性组),稳定期51例(稳定组);另外选择同期来本院体检的90例健康志愿者作为对照组。比较三组基本资料及UA、Cr、cys C、BNP水平。将急性期患者依据气流受限程度分为轻度组(n=16)、中度组(n=16)、重度组(n=13),比较三组UA、Cr、cys C、BNP水平,并分析UA、Cr、cys C、BNP水平与急性期患者气流受限程度的相关性。【结果】与对照组相比,急性组、稳定组吸烟史占比显著增高,差异有统计学意义(P<0.05)。急性组、稳定组、对照组UA、Cr、cys C、BNP水平依次降低,组间比较差异均具有统计学意义(P<0.05);重度组、中度组、轻度组UA、Cr、cys C、BNP水平依次降低,组间比较差异均具有统计学意义(P<0.05)。Spearman相关性分析结果显示:UA、Cr、cys C、BNP水平与急性期患者气流受限程度呈正相关(P<0.05)。【结论】COPD患者外周血中UA、Cr、cys C和BNP水平异常,其与COPD患者病情严重程度显著相关。【Objective】To investigate the expression levels and significance of renal function indicators such as uric acid(UA),creatinine(Cr),cystatin C(cys C)and B-type brain natriuretic peptide(BNP)in peripheral blood of patients with chronic obstructive pulmonary disease(COPD).【Methods】A total of 96 patients with COPD admitted to our hospital from May 2020 to June 2022 were selected,including 45 patients in the acute stage(acute group)and 51 patients in the stable stage(stable group).In addition,90 healthy volunteers who came to our hospital for physical examination during the same period were selected as the control group.The basic data and UA,Cr,cys C and BNP levels of the three groups were compared.Patients in the acute stage were divided into mild group(n=16),moderate group(n=16)and severe group(n=13)according to the degree of airflow limitation.The levels of UA,Cr,cys C and BNP in the three groups were compared,and the correlation between the levels of UA,Cr,cys C and BNP and the degree of airflow limitation in the acute stage was analyzed.【Results】Compared with the control group,the smoking history ratio of the acute group and stable group was significantly increased,and the difference was statistically significant(P<0.05).The levels of UA,Cr,cys C and BNP in the acute group,the stable group and the control group were decreased successively,and the differences among groups were statistically significant(P<0.05).The levels of UA,Cr,cys C and BNP in severe group,moderate group and mild group were decreased successively,and the differences among groups were statistically significant(P<0.05).Spearman correlation analysis showed that the levels of UA,Cr,cys C and BNP were positively correlated with the degree of airflow restriction in acute patients(P<0.05).【Conclusion】The abnormal expression levels of UA,Cr,cys C and BNP in peripheral blood of patients with COPD are significantly correlated with the severity of COPD.

关 键 词：肺疾病 慢性阻塞性 肾功能试验 

分 类 号：R563.9[医药卫生—呼吸系统]